[Neuroprotective effect of aerobic training against lead induced oxidative stress in rat cerebellum]

Oxidative damage associated with the presence of Lead in the brain has been proposed as one possible molecular mechanism involved in Lead toxicity. Aerobic exercise is known to protect the brain through a cascade of molecular and cellular processes. The purpose of this study was to investigate the effect of 8 week aerobic training on the brain-derived neurotrophic factor [BDNF] and malondialdehyde [MDA] levels in rat's cerebellum exposed to Lead acetate. In this experimental study, 40 Male Wistar rats were randomly allocated into four groups: sedentary base, sham [30 mg/kg of ethyloleate], Lead and exercise+Lead [20 mg/kg Lead acetate, intraperitoneally]. The exercise program consisted of progressive running training on the treadmill for 15 to 22 m/min, 25 to 64 min/day, and 5 days/week for 8 weeks. BDNF and MDA levels were measured by ELISA and TBARS methods, respectively. Chronic Lead acetate administration enhanced significantly [P<0.05] cerebellar MDA levels in rats compare to base and sham groups but had no effect on BDNF levels. Cerebellar MDA significantly was reduced and BDNF non significantly was increased in Lead acetate+ training group. Regular aerobic exercise with moderate intense may exert role neuroprotective against Lead-induced cerebellar injury by down-regulating oxidative stress and promotes brain health through increases in BDNF

[ comparison of acute aerobic and resistance training method on plasma fibrinogen concentration in young women]

Fibrinogen, an inflammatory marker as well as a fundamental part of the coagulation cascade, is suggested to play a significant role in the pathogenesis of atherosclerosis and complications of atherothrombotic diseases. This study was carried out to assess the comparison of acute aerobic and resistance training method on plasma fibrinogen concentration in young women. This semi-experimental study was done on twenty trained volunteer women students, which was selected objectively, and availability. The subjects were randomly divided into two groups of aerobic [n=10] and resistance training [n=10]. Aerobic group performed exhaustive workout program on treadmill intensity 65 to75% of Vo2max on treadmill. The resistance group completed three sets of 5-7 repetitions of six exercises at an intensity corresponding to 80% of 1RM. Following 12 to 14 hours of nightly fasting, venous blood samples [5 cc] were collected pre, immediately after exercise and after 60 min of recovery and analyzed for fibrinogen content. Participants were matched according to anthropometric measurements, age, fat percentage and Vo2max. Data tested by using independent t, repeated measures analysis of variance and post-hoc test least significant difference [LSD] [P