ABSTRACT
Gastric cancer is the second most common cause of cancer related death in the world. Helicobacter pylori infection is associated with chronic gastritis, a known precursor of gastric cancer. Carcinomas have been shown to be related to a high prevalence of H.Pylori infection. We study titer of H.Pylori antibody in patients with gastric cancer and in patients with non-ulcer dyspepsia. During an eleven-month course [October 2001- September 2002] we studied the relation between H. Pylori infection and gastric carcinoma in a case - control study in Zahedan hospitals. The subjects divided into two groups; 40 control subjects and 40 patients with gastric carcinoma. IgG Antibody to H. Pylori was checked in serum of patients in both groups by ELISA method. Each group comprised of 21 male [52.5%] and 19 female [47.5%]. Mean age was 53.18 and 56.58 years in control and case group, respectively. Anti-H Pylori IgG was positive in 100% of patients with gastric carcinoma but only in 28% of the control subjects. Chi-test demonstrated a significant correlation between gastric cancer and Antibody test. [P= 0.000]. Patients with gastric carcinoma had higher titer of IgG 85.67 in contrast to those who did not have cancer. Like other epidemiologic studies this study revealed that H pylori infection is associated with an increased risk of gastric carcinoma and is considered as a cofactor in the pathogenesis of this malignant condition