Synthesis of some 1,3,4-oxadizolines and thiazolidinones of expected anti-bacterial activity

Reaction of the acid hydrazide [3] with different carbonyl compounds gave the corresponding hydrazones [4]. The oxadiazolines [5] were obtained by refluxing [4] with acetic anhydride. The thiazolidinones [6] were achieved by the cyclocondensation of [4] with mercaptoacetic acid. The antimicrobial activity was determined for eight representative compounds and some of them were active