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1.
Egyptian Journal of Pharmaceutical Sciences. 2007; 48: 27-37
in English | IMEMR | ID: emr-82358

ABSTRACT

From the aerial parts of Lotus hebranicus L. Hochst ex Brand a total of seven flavonoid compounds were isolated and identified as: Kaempferol- 3-0- sophoroside -7-0-rhamnoside, kaempferol-3-0-sophoroside, isorhamnetin-3-0-glucoside-7-0-rhamnoside kaempferol-3,7-di-0-rhamnoside, kaempferol-7-0-rhamnoside, isorhamnetin and kaempferol. A study of toxicological and ulceroprotective effects was performed for both Lotus hebranicus L. Hochst ex Brand and Lotus corniculatus L


Subject(s)
Animals, Laboratory , Plant Extracts , Ulcer , Rats , Plant Extracts/toxicity , Mice , Flavones
2.
Egyptian Journal of Pharmaceutical Sciences. 2006; 47: 1-11
in English | IMEMR | ID: emr-182229

ABSTRACT

From the aerial parts of Retama raefam ten flavonoids were isolated and identified as saponarin, genistein 8-C-glucoside, genistein 5-O- methylether, genistein 5,4'-di-O-methylether, alpuminoisoflavone, ephedroidin, luteolin, apigenin and two new flavones, luteolin 4'-O- neohesperidoside and 5,4'-dihydroxy- [3",4''- dihydro- [3",4"-dihdroxy] -2",2"dimethylpyrano [5",6":7,8]-flavone[1]. In vitro antitumor screening of genistein-5-O-methylether and genistein-8-C-glucoside were carried out on sixty human tumor cell lines


Subject(s)
Humans , Antineoplastic Agents , Isoflavones , Glucosides/isolation & purification , Genistein/isolation & purification , Chromatography, Gas/statistics & numerical data
3.
Bulletin of Faculty of Pharmacy-Cairo University. 1999; 37 (3): 149-153
in English | IMEMR | ID: emr-50491

ABSTRACT

Three known cardenolides [Strophanthidin [1], Corchoroside A [2] and Olitoriside [3]] were isolated from the seed-leaves of Corchorus olitorius L. [Tiliaceae]. The cytotoxic activity was evaluated against six cancer cell lines. Compounds 2 and 3 were very potent and their EC50 values against A549 [human lung carcinoma] were 0.06 mug/ml and 0.025 mug/ml, respectively. These compounds were isolated for the first time from the seed-leaves of the plant and this was the first report of the cytotoxicity of compounds 2 and 3


Subject(s)
Plant Leaves/chemistry , Seeds/chemistry , Plants , Strophanthidin , Plant Extracts
4.
Bulletin of Faculty of Pharmacy-Cairo University. 1998; 36 (1): 11-6
in English | IMEMR | ID: emr-47767

ABSTRACT

In the present study testosterone and estriol as well as their precursor cholesterol were isolated for the first time from petroleum ether extract of Punica granatum L. seeds, in addition to estrone and estradiol previously isolated. Beta-sitosterol and stigmasterol were also isolated from the unsaponifiable fraction. The oily fraction of petroleum ether extract containing hormones showed only estrogenic-like action


Subject(s)
Animals, Laboratory , Steroids/analysis , Testosterone/isolation & purification , Estriol/isolation & purification , Plant Extracts/analysis
5.
Egyptian Journal of Pharmaceutical Sciences. 1997; 38 (1-3): 209-220
in English | IMEMR | ID: emr-44542

ABSTRACT

The study included the investigation of saponin contents in Aerva lanata [L.] Juss ex. Schult and Aerva javanica [Burm. fil] growing in Egypt. The crude saponin mixture was prepared and purified by MgO method, further purification of the isolates was carried out by column chromatography followed by centrifugally accelerated rotatory TLC. Three glycosides were isolated. Hydrolysis of glycoside 1 afforded beta-sitosterol and glucose, saponin glycoside, yielded lupeol, galactose and glucose, while saponin glucoside, gave oleanolic acid, galactose, glucose and rhamnose. The genins were identified on the basis of mp, mmp, chromatographic behavior IR, 1HMR and EI-mass spectra. The sugar moieties of the glycosides were identified by PC and GLC analysis. Quantitative estimation of saponin applying the hemolytic index method revealed that it is higher in A. javanica [0.09%] than in A. lanata [0.014%]. Identification of the hydrocarbons, sterols and triterpenes was achieved by chromatographic as well as GC-MS analysis. beta-Sitosterol, campesterol, stigmasterol, stigmasterol acetate and lupeol were identified in both species. Olean-12-en-28 oic acid 3,16 dioxomethyl ester and ergosterol were identified in A. lanata, while oleanolic acid methyl ester was identified only in A. javanica. The total fatty acids of the two species were methylated and analyzed by GLC. The results revealed the presence of lauric, myristic, myrstoleic, palmitolleic, stearic, oleic and linoleic acids in the two aerva species. Palmitic acid was found only in A. javanica


Subject(s)
Saponins/isolation & purification , Medicine, Traditional , Plants, Medicinal
6.
Egyptian Journal of Pharmaceutical Sciences. 1992; 33 (1-2): 319-325
in English | IMEMR | ID: emr-23691

ABSTRACT

Acacia nilotica L. Willd. and Acacia farnesiana L. Willd. [leguminosae] are of wide spread occurrence in the Delta around the Nile banks and had been used in Egyptian folk medicine. Mucilage was isolated from these two species in yield of 8.2 and 10.8% respectively. PC, TLC and GLC studies of the mucilage hydrolysate of the pods of each of the two species revealed the presence of arabinose, xylose, galactose, mannose in the ratio [2: 2: 1: 2] in A. nilotica and of arabinose, xylose, galactose, glucose, mannose in the ratio [3: 2: 1: 2: 3] in A. farnesiana. No previous reports were traced concerning the presence of mucilage in the two species


Subject(s)
Acacia , Medicine, Traditional , Gum Arabic
7.
Egyptian Journal of Pharmaceutical Sciences. 1992; 33 (5-6): 789-797
in English | IMEMR | ID: emr-23729

ABSTRACT

B-sitosterol, [alpha, B-marlin and betulin], fatty acids, pectin and herniarin were detected for the first time in the corms of Colchicum ritchii [R.Br.]. The structure of the isolated compounds was identified through chromatographic as well as spectroscopic techniques


Subject(s)
Chemistry , Pharmacology
8.
Egyptian Journal of Pharmaceutical Sciences. 1985; 26 (1-4): 317-20
in English | IMEMR | ID: emr-5581
9.
Egyptian Journal of Pharmaceutical Sciences. 1985; 26 (1-4): 321-33
in English | IMEMR | ID: emr-5585

Subject(s)
Plants
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