[Epidemiology of colorectal cancer in Isfahan Province]

The aim of this study was to assess epidemiology of colorectal cancer [CRC] in Isfahan, Iran. Data were gathered from hospital documents of hospital admissions for colonoscopy, surgery, chemotherapy or radiotherapy due to colorectal cancer during 1996-2003. 1100 cases with colorectal cancer in seven years were detected and reviewed. Our minimum incidence rate estimation was 1.3 per 100,000 in 1996, 3.7 /100,000 in 2001 and 3.1 / 100,000 in 2003. One third of CRC cases were diagnosed between thirties to fifties in both genders in our province with a peak incidence in the fifties for females and in the sixties for males. CRC in more than 85% of the patients was left sided. The one, five and seven year's survival rates were 97%, 43% and 21% respectively. A significant lower survival rate was seen in right colon in oppose to the left colon [13% vs. 40%] [p<0.05] after five years of follow up. Incidence of CRC in Isfahan Proviene is increasing. Rectum is the most common site [61.6%] for CRC. Many of Iranians who have CRC are young Regarding to fact program, Screening is recommended earlier than Western countries

[ obsessive - compulsive disorder: prevalence and therapy in psychiatric clinic clients at Nour hospital of Isfahan [1995-1997]]

Background: The obsessive-compulsive disorder [OCD], is a common psychiatric disease and in spite of long-term treatment, its failure to therapy, discontinuing, relapse and side effects are high

Objective: This study was done to assess the patterns of OCD, prevalence, therapies and comorbidity in Nour psychiatric clinic clients

Methods: Within 3515 psychiatric consultation during 4 years, 166 cases of OCD were recognized. The time of initial and complete drug effects considered 3 and 6 weeks respectively. The response to therapy [after 6 weeks] was: 1] Good: symptoms remove, 2] Medium: symptoms relief, 3] Poor: no symptoms control

Findings: The prevalence of OCD were 4.72%, mainly women, married and adult with 20-40 years old. The most pattern of OCD was washing, thinking and checking, respectively. The most used drug was clomipramine [66.87%] then fluoxetine [19.27%], with dosage 61-100 and 20 [mg/d] respectively. In group 1, the mean dose of clomipramine and fluoxetine was 69 and 60 [mg/d]. Only 30.1% of cases had been followed up, and 13.2% of them had good response to therapy. The comorbidity was in 68.08% of cases, and in 80.64% of them, the response to therapy was mild. The most psychiatric comorbidity was major depression disease [44.57%]

Conclusion: The prevalence of OCD is high. The most used drug [insufficient and not enough], was clomipramine then fluoxetine. The psychiatric comorbidity [specially major depression disease] had raised failure rate