Assessment of thyroid function in patients with. Dysmetabolic syndrome [DS]

The DS is a highly prevalent clinical entity and primarily a lifestyle disease with significant morbidity and premature mortality. We hypothesized that thyroid dysfunction may be relevant to the DS. We studied thyroid function [total T3, total T4, TSH, basal and after 20 and 60 minutes of IV injection of 200 micro g TRH] in thirty five type 2 diabetic patients with DS, in addition to ten age and sex -, matched controls. Fasting serum insulin, S cortisol, S uric acid, and lipogram were also performed for all participants after complete clinical history taking and examination. Body mass index [BMI], Waist [W], hip [H], W/H ratio together with blood pressure measurements were significantly higher in patients than in controls [P<0.001 each]. Furthermore, S cortisol, S insulin and S uric acid were significantly higher in patients than in controls [P< 0.001 each]. In addition total cholesterol [TC], triglyceride [TG], and LDL were significantly raised in patients than in controls while HDL was significantly reduced in patients than in controls [P<0.001 each]. Basal T3, T4, and TSH were not different in patients and controls. However, following TRH injection particularly after 60 minutes, patients were classified into three groups; Group I which had normal thyroid function in 25 patients [71.4%], Group II which had sub-clinical primary hypothyroidism in 4 patients [11.4%], and Group III which had secondary hypothyroidism in 6 patients [17.2%]. All patients with group II and 5 out of 6 patients with group III were females. Moreover, TSH response to TRH injection after 60 minutes was correlated significantly positively with S cortisol [r=.477, P<0.01], S insulin [r=.743, P<0.01,], S uric acid [r=.335, P<0.05], TC [r=.317, P<0.05] and LDL [r=0326, P<0.05,] and correlated significantly negatively with HDL [r= -.341, P<0.05]. The clustering of metabolic abnormalities in DS suggested underlying hormonal disturbances not only in insulin but also in thyroid dysfiunction in the form of sub-clinical hypothyroidism and suspected disturbed hypothalamo - pituitary - adrenal axis. However such conclusions should be re- evaluated on a large number of patients aiming to elucidate a possible dysfunction of hypothalamo -pituitary-thyroid axis in DS

Review and analysis of fire events in Egypt

Fire events are potentially significant of public risk, there is a need for an analytical approach to predict their frequencies and reduce their threats. Analysis and review of fire incidents may throw light upon the importance of assessing fire hazards and could help in a deep underst and ing of fire protection concepts and requirements. This study displays a review and analysis of fire incidents in Egypt during 12 years from January 1980 to December 1991. The statistical methods of analysis include frequency distribution histograms, analysis of variance as well as regression and correlation analysis. The investigation can be divided into three main parts: Analysis of the total fire incidents [TFI], important fire incidents [IFI] and significant fire incidents [SFI]. The analyses include the distribution of fire events and their losses, the primary causes, the classification of events according to the place of occurrence and the study throws some light on arson fire events

Results of surgical repair of huge incisional hernia using prolene mesh

Fifty patients with huge abdominal wall incisional hernias were treated using prolene mesh in double folded manner from period of 1986 to 1993. Forty patients were females [80%], ten patients were males [20%], average age was 40 + 2 years. The most important etiological causative factors of incisonal hernia were as follows: burst abdomen in 20 patients [40%], postoperative wound infection in 16 patients [32%], bad surgical repair in 8 patients [16%] and persistent postoperative straining in 6 patients [12%]. Surgical repair using double folded prolene mesh proved to be superior, 45 patient [90%] had excellent results with nice postoperative period and follow up for 2-4 years. 5 patients [10%] got recurrence which was attributed to severe postoperative wound infection and revision repair was done after 6 months. Highest incidence of incisional hernias occurred in obese multiparous females especially after mid line incisions for cesarean section