Anti-salmonella activity of azithromycin

The in vitro activity of the new azalide azithromycin was evaluated by a standardized agar dilution method against recent clinical isolates of salmonella typhi [88 strains] and salmonella species [91 isolates]. The results were compared with five other commercially available standard drugs. All the isolates of s. typhi were inhibited by 2-16 mg/l of azithromycin as compared to 2-8 mg/l for other salmonella species. Minimum inhibitory concentration range of azithromycin against salmonella was similar to chloramphenicol but superior to ampicillin augmentin erythromycin and tetracycline