ABSTRACT
Background and aim: The postoperative pain control is performed with different methods [regional anesthesia, acupuncture, music therapy,] or drugs such as opioids, NSAIDs and Ketamine. In many researches, Metoclopramide is used for decreasing postoperative pain. The aim of this study was to compare the effect of Metoclopramide [M] and Ketamine [K] as a preemptive analgesia on postoperative pain
Methods: In a double blinded clinical trial study 86 ASA 1 and 2 patients enrolled in this study and divided into two groups of Metoclopramide [M] and Ketamine [K]. Half an hour before the operation patients in group M and group K received 10 and 0.3 mg/kg, i.v. Metochlopramide and Ketamine, respectively. The pain scores and the amounts of opioid consumption in recovery room and first 24 hours and the postoperative complications such as nausea, vomiting, irritability and psychological problems were recorded. Data were analyzed using student-t test, ANOVA and Chi-square statistical analysis
Results: There was no significant difference in demographic data including weight, age, sex, duration of surgery and basic hemodynamic parameters between two groups [P>0.05]. The pain score was lower in Metoclopramide group [3.98+/-3.04] compared to the Ketamine group [5.93+/-3.32] in recovery room and first 24 hours after surgery. In addition, there was a statistical difference in the frequency of drug's side effects in group M [30.02%] and the group K [95.3%] [P<0.001]. The extubation time was significantly longer in Ketamine group [5.3+/-0.8] than Metoclopramide group [7.4+/-0.7] [P<0.05]
Conclusion: The results of this research showed that administration of Metochlopramide before induction of anesthesia was more effective than Ketamine for reducing postoperative pain, which suggests analgesic effects of Metoclopramide