ABSTRACT
There is increasing evidence for the role of oxidative stress in female reproductive tract. The purpose of this study was to determine the activity of antioxidant enzymes during menstrual cycle. In addition, the relationship between activity of antioxidant enzyme and sex hormones was evaluated. In this study the activity of superoxide dismutase, glutathione peroxidase, glutathione reductase, catalase and total antioxidant capacity during the menses, follicular and luteal phases of the menstrual cycle in twenty women with regular menstrual cycle were studied. Furthermore, the correlation between activity of antioxidant enzymes and estradiol, progesterone, LH, FSH and testosterone were evaluated, There was no significant difference between activity of superoxide dismutase, glutathione peroxidase, glutathione reductase, catalase and total antioxidant capacity during the menses, follicular and luteal phases of the menstrual cycle [P>0.05]. We found significant correlation, in luteal phase, between superoxide dismutase and FSH [P<0.05
ABSTRACT
Background: evaluation of the diagnostic value of silver nucleolar organizer Region assessment in skin diseases is important. According to this reason, we want to study the Argyrophilic Nucleolar Organizer Region [Ag-NOR] count and Subjective Ag-NOR Pattern Assessment [SAPA] score in normal skin, Squamous Cell Carcinoma [SCC], Basal Cell Carcinoma [BCC] and Solar Keratosis [SK]
Materials and Methods: the study groups consisted of 69 cases [18 SCC, 18 SK, 17 BCC and 16 Normal skin]. The specimens were studied by microscope which were prepared by H and E staining and silver staining for Ag-NOR
Results: the mean count in SCC was 2.92, in SK 2.29 and in BCC 1.59, which was statistically significant compared to 0.93 in normal skin [p value <0.001]. The SAPA score was in SCC 7.94 in SK 7.61 in BCC 6.35 and in normal skin 5.00 [p value <0.001]
Conclusions: Ag-NOR count and SAPA score in normal and pathological status of skin has positive results