Late onset central hypoventilation syndrome with hypothalamic dysfunction in a kuwaiti girl

Late onset central hypoventilation syndrome [LO-CHS] is now considered a well-established disease that develops in previously normal children after infancy and has been regarded as a distinct entity from the congenital central hypoventilation syndrome [CCHS]. Both conditions are associated with neural crest tumours, but hypothalamic dysfunction [HD] is a feature of LO-CHS and not CCHS. We report a case of LO-CHS with HD [LO-CHS / HD] who presented in respiratory failure at the age of five years