ABSTRACT
Objective: To evaluate the plasma interleukin-10 [IL-10] levels in patients suffering from dengue hemorrhagic fever between 4 to 7 days of onset of disease and 24 hours after the first sample, to find out the association of plasma IL-10 levels with the outcome. Study Design: Analytical study. Place and Duration of Study: All major hospitals of Lahore, Pakistan, from August to November 2012
Methodology: Participants included 50 registered patients of dengue hemorrhagic fever [DHF] aged between 15 - 50 years. Plasma IL-10 concentrations were measured on above stated day. Outcome was described as recovery and shock. Platelet count and hematocrit percentages were also recorded. Statistical analyses were done using SPSS version 19. A p-value
Results: Plasma IL-10 levels were found to be raised in DHF patients and were associated with fatal outcome [p=0.004]. In recovered DHF patients, plasma IL-10 levels decreased after 24 hours [mean 26.54 +/- 16.03 pg/ml] as compared to admission time [mean 74.39 +/- 61.69 pg/ml] but in case of DHF patients suffering from shock, plasma IL-10 was found to be higher after 24 hours [mean 87.69 +/- 7.77 pg/ml] as compared to levels at admission time [mean 42.56 +/- 28.09 pg/ml]. ROC curve analysis revealed a change [30 units pg/ml] of plasma IL-10 concentration, within 24 hours of admission, raised from the base line to be 105 times more critical for shock in DHF patients [100% sensitivity and 71.4% specificity, p < 0.001]
Conclusion: Elevated plasma IL-10 is a potential predictor of disease severity and fatal outcome in DHF patients