ABSTRACT
After initial period of shock, infection remains a major and most serious complication in burn patients. The flora of the burn wound is constantly changing and the potential risk of burn wound sepsis persists until complete healing of burn wound. In burn patients most of the infections are thought to be of nosocomial origin. Gram positive cocci are considered with increasing frequency in nosocomial infection. Gram negative organism cause trouble in different ways, pus containing toxins convert partial thickness burns into full thickness burn, causing general illness, failure of graft taking and most important is septicemia Pseudomonas aeruginosa is highly pathogenic in the injured immuno suppressive burn patients. Most common isolates belongs to family Enterobacteriacae i.e. 36 [63.3%]. Second common isolates were belonging to Genus Staphylococci 15 [26%]. The prevalence of Pseudomonas aeruginosa was relatively less that was 07 [10.4]. Gram positive Staphylococci were 100% sensitive to Vancomycin, Chloramphenicol, and Imipenem. Pseudomonas aeruginosa were highly sensitive to Ciprofloxacin and Amikacin i.e. 83.3% Imipenem was highly effective against [97.6%] isolates of Enterobacteriacae. Ciprofloxacin was the second most effective drug that was effective against 87.5%isolates of Enterobacteriaicae