ABSTRACT
The main objective of the present study is to determine the histopathological patterns and diagnostic value of endometrial curettings in patients presenting with abnormal uterine bleeding. A prospective study. This study was conducted at Department of Pathology Liaquat University of Medical and Health Sciences Jamshoro during March 2010 to February 2011. A total of 100 cases of endometrial curettage were processed for routine staining with Haematoxylin and Eosin and slides were evaluated for histopathological diagnosis. The results showed that patient's age ranged between 40-52 years and most of the patients about 77%presented with menorrahgia. The histological findings showed normal phase [Proliferative and Secretory phase] of menstrual cycle in 52% of cases followed by simple hyperplasia without atypia 23%, chronic endometritis 13%,polyp 2%, tuberculous endometritis 2%, anovulatory cycle 1%, anovulatory cycle with chronic endometrits 1%,atrophic changes 1%, atypical complex hyperplasia 2% and malignancy in 3% of cases. The Simple hyperplasia23% and chronic endometritis 13% were the commonest pathological alteration. The accidental findings of organic lesions including polyps and malignancy in 5% cases focused the diagnostic importance of curettage in patients presenting with abnormal uterine bleeding. It is concluded that simple hyperplasia without atypia and chronic endometritis are most important causes of abnormal uterine bleeding in the perimenopausal age groups
Subject(s)
Humans , Female , Adult , Middle Aged , Uterine Hemorrhage , Menorrhagia , Prospective Studies , Endometrium/pathologyABSTRACT
Aim of this study is Immunohistochemical analysis of H and E diagnosed cases of NHL for confirmation, classification and differentiation on the basis of phenotypic expression of CD3, CD30, CD45 and CD20 markers. Prospective study. This study was conducted in the Pathology department of Liaquat University of Medical and Health Sciences Jamshoro [LUMHS] during October 2010 to March 2012. The sample consisted of all the specimens received in the Pathology department of Liaquat University of Medical and Health Sciences Jamshoro [LUMHS] during the above period. Immunohistochemical stains including CD3, CD30, CD20 and CD45 were used for classification and differentiation of cases of NHL. Out of one hundred and eighty [180] H and E diagnosed cases of Non Hodgkins Lymphoma, only 142 [78.8%] were positive for CD20 and were confirmed as B cell NHL; however 6 [3.3%] cases showed positivity with CD30 and were confirmed as large T-cell NHL. 38[21.2%] cases showed positivity for CD3 and all 180 [100%] cases were positive for CD45 and were confirmed as NHL. It is concluded that Immunohistochemistry is helpful in differentiation of NHL. Cases of B cell NHL occur more frequently than T cell NHL. Furthermore NHL is more common in males and mostly presents with nodal involvement
ABSTRACT
The aim of this study was to evaluate the patterns of Beta Thalassaemia in children suffered with microcytic hypochromic anemia in the different hospital of Hyderabad region. Cross-sectional study. This is an experimental based research study that was conducted at Isra University Hospital, Hyderabad and Liaquat University of Medical and Health Sciences Hospital Jamshoro Hyderabad from June 2011 to February 2012. Hundred [100] children from either gender attending outpatient department of Isra University Hospital and Liaquat University Hospital Hyderabad were selected for this study. Whole blood sample [10ml] was collected from each children. Peripheral smears were made and found that all children have suffered with findings of microcytic hypchromic anemia. Children with other than microcytic hypochromic anemia were excluded from this study. All parents of children were interviewed regarding family history and marriages with cousin and other findings or histories were also recorded on a well designed performa. Whole blood samples were analyzed for the evaluation of the patterns of Beta Thalassaemia in 100 children who were affected with microcytic hypochromic anemia. Out of 100 children, 08 of them were diagnosed as having beta thalassaemia minor, one as Beta Thalassaemia major and the remaining 91 were non thalassaemics. Among 08 Beta Thalassaemic minor children, 05 were females and 03 were males and only one male child was suffered with beta thalassaemia major. It is concluded that the prevalence level of beta thalassaemia is higher in Hyderabad, which is an alarming. Many factors such as poor facilities for diagnosis, lack of awareness among clinicians, consultants and pathologists and high cost of molecular diagnosis play a contributory role in the propagation of the beta thalassaemia in the Pakistani population. These factors become a serious hindrance for the prevention of thalassaemic program in Pakistan