ABSTRACT
Objective: To assess the frequency of sarcopenia in type 2 diabetes mellitus [DM] patients using different formulas of bioimpedance analysis [BIA]
Study Design: Cross-sectional study. Place and Duration of Study: Obesity Clinic, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey, between March and June 2015
Methodology: The present study included DM patients at >/= 18 years of age with BMI >/= 30 kg/m[2]. BIA measurements consisted of body weight, height, total muscle mass and sum of the muscle masses of the four limbs [ALM]. Skeletal muscle index, total muscle index, skeletal muscle percentage, total muscle percentage, and ALM/BMI were used for muscle-related analyses. The data were presented as frequency, mean +/- standard deviation, and percentage. Student t-test was used to compare differences between two independent groups
Results: A total of 295 DM patients were enrolled in the study, of whom 176 [59.66%] were females, 119 [40.34%] were males, 47 [15.93%] were over the age of 65 years, and the mean age was 53.39 +/- 10.39 years. Sarcopenia was determined in 40 males [33.61%] by body muscle ratio, in 15 males [12.60%] by ALM/BMI ratio, and in one male participant [0.84%] by skeletal muscle index. Among female participants, while sarcopenia was determined in 61 [34.65%] by body muscle ratio and in 1 [0.56%] by ALM/BMI ratio, no sarcopenia case was detected using skeletal muscle index
Conclusion: The frequency of sarcopenia in obese diabetic patients is found to be lower when skeletal muscle index and ALM/BMI ratio is used, but higher with body muscle ratio
ABSTRACT
Objective: To assess the relation between bioimpedance measurements and metabolic parameters and C-peptide in patient with type 2 diabetes mellitus [DM]. Study Design: Cross-sectional study. Place and Duration of Study: Kartal Dr Lutfi Kirdar Training and Research Hospital, Pendik Kaynarca Diabetes Center, Exercise and Metabolism Unit, between January and March 2015
Methodology: Patients with DM, aged less than 65 years, were assessed for bioimpedance analysis, fasting plasma glucose [FPG], HbA1c, C-peptide levels, triglyceride levels, LDL-cholesterol, and HDL-cholesterol levels. Skeletal muscle index, total muscle index, skeletal muscle percentage, and total muscle percentage were used for muscle-related analyses. Mann-Whitney U-test or independent t-test were used to compare differences between two independent groups. Pearson correlation test or Spearman correlation test were used to find out correlation between variables
Results: A total of 359 DM patients were enrolled in the study. Mean age was 51.6 +/- 8.0 years, and 278 [77.7%] of the participants were females. After adjusting age and gender variables, there was no relation between muscle-related measurements and FPG, triglyceride, LDL-cholesterol [p>0.05]. However, there was muscle-related indexes [MRI] positively correlation with C-peptide and inversely associated with HDL-cholesterol [p<0.05]
Conclusion: Muscle-related indices positively correlated with C-peptide, which showed endogenous insulin reserve