ABSTRACT
This study was conducted to delineate the clinical pattern of a cohort of Pakistani male patients with systemic lupus erythematosus [SLE]. Clinical and laboratory data were collected of 24 male patients who were diagnosed with SLE and admitted to a tertiary care hospital between 1986 and 2001. Imaging and invasive studies [including aspirations and biopsies] were also recorded. Fourteen patients [58%] had renal involvement, with WHO class 4 and 5 comprising 89% of the cases. Eight patients [33%] had neurological involvement. Out of these 8 patients, 3 presented with psychosis [12.5%] and 4 [17%] with seizures. Twenty three patients [96%] had hematological involvement, 6 [25%] had serosal and 10 [41%] had articular involvement. Cutaneous lesions were noted in 10 [41%] patients. A majority of the patients were noncompliant and were lost to follow-up; therefore, ultimate outcome could not be clearly delineated. A high index of suspicion for SLE in males may permit early diagnosis and dictate the need for more aggressive therapy
ABSTRACT
Associating systemic lupus erythematosus [SLE], with an initial presentation of hemolytic uremic syndrome [HUS] is rare. We report a case of 21-year old Afghani female admitted to our hospital with an initial complaint of high grade fever and diffuse maculopapular rash and swelling of lower limbs. Diagnosis of atypical HUS was established according to the clinical triad of HUS without a veriotoxin-producing organism in her stool and the pathological finding compatible to thrombotic microangiopathy. In addition, her symptoms fulfilled the 1982 revised criteria for the classification of SLE. After pulse methylprednisolone, cyclophosphamide and plasmapheresis therapies, her laboratory findings and general condition improved. Unfortunately she was lost to follow up as she decided to return back to Afghanistan