ABSTRACT
To determine the diagnostic accuracy of risk of malignancy index [RMI] in the preoperative prediction of malignancy in ovarian masses by taking histopathological findings as gold standard. Cross-sectional survey. This study was conducted at Gynae Unit 111, Lady Willingdon Hospital Lahore and duration was one year from 1.1.2013 to 31.12.2013. 140 cases were recruited for the study. Blood drawn for serum Ca-125 level and sent to hospital laboratory and pelvic ultrasound was done. For each risk of malignancy index was calculated value of RMI >/= 200 was taken as positive. Patients were having the mean age 55.8+/-7.6. Comparison of malignancy index vs. histopathology for prediction of malignancy in ovarian masses showed 64 malignant cases on histopathology and 69 on RMI.Sensitivity rate: 89.0%, specificity: 84.2%, diagnostic accuracy: 86.4%, PPV: 82.6% and NPV: 90.1%.The menopausal status, serum CA125 levels and ultrasound reports accumulated together can give us risk of malignancy index which can provide the odds of development of ovarian malignancies