ABSTRACT
We performed a retrospective study to evaluate the feasibility and safety of extensive upper abdominal surgery (EUAS) in elderly (> or =65 yr) patients with advanced ovarian cancer. Records of patients with advanced epithelial ovarian cancer who received surgery at our institution between January 2001 and June 2005 were reviewed. A total of 137 patients including 32 (20.9%) elderly patients were identified. Co-morbidities were present in 37.5% of the elderly patients. Optimal cytoreduction was feasible in 87.5% of the elderly while 95.2% of young patients were optimally debulked (P=0.237). Among 77 patients who received one or more EUAS procedures, 16 (20.8%) were elderly. Within the cohort, the complication profile was not significantly different between the young and the elderly, except for pleural effusion and pneumothorax (P=0.028). Elderly patients who received 2 or more EUAS procedures, when compared to those 1 or less EUAS procedure, had significantly longer operation times (P=0.009), greater blood loss (P=0.002) and more intraoperative transfusions (P=0.030). EUAS procedures are feasible in elderly patients with good general condition. However, cautious peri-operative care should be given to this group because of their vulnerability to pulmonary complications and multiple EUAS procedures.
Subject(s)
Adult , Aged , Female , Humans , Middle Aged , Abdomen/surgery , Age Factors , Disease-Free Survival , Gynecologic Surgical Procedures/adverse effects , Ovarian Neoplasms/mortality , Retrospective Studies , Treatment OutcomeABSTRACT
OBJECTIVE: Human cervical cancer is caused by the high-risk types of human papillomavirus (HPV) such as HPV16, which possess the E6 and E7 oncogenes, whose expressions are a prerequisite for cancer development. We performed this study to compare the efficacy of antitumor activity by HPV siRNA which silences only E6 or both E6/E7. METHODS: We transfected siRNA 377 (HPV16 E6 siRNA), siRNA 3 (HPV16 E6 siRNA), and siRNA 198 (HPV16 E7 siRNA) into SiHa cell line (siRNA 377 silences only E6, and siRNA 3 and siRNA 198 silence both E6 and E7). We experimented cell counts and morphologic changes 24 and 48 hours after transfection and expressions of HPV16 E6/E7 mRNA by RT-PCR. RESULTS: siRNA 377, siRNA 3, and siRNA 198 suppressed the cell growth. siRNA 3 and siRNA 198 were more potent than siRNA 377 in cell growth suppression. siRNA 377 knocked down the expression of E6 mRNA, and both siRNA 3 and siRNA 198 knocked down the expression of E6/E7 mRNA. CONCLUSION: Our results suggest that simultaneous suppression of E6 and E7 was more potent than E6-specific suppression in cancer cell growth.
Subject(s)
Humans , Cell Count , Cell Line , Oncogenes , RNA, Messenger , RNA, Small Interfering , Transfection , Uterine Cervical NeoplasmsABSTRACT
The mature cystic teratoma of the ovary (ovarian dermoid cyst) is the most common ovarian neoplasm in young women and comprises approximately 10~25% of all ovarian tumors. There are many complications such as torsion, rupture, infection, suppuration, and rarely malignancy change. Teratoma derives from the three embryonic cell lines and may contain skin, sebaceous tissue, hair, cartilage and bone, neuroglial tissue, gastrointestinal and respiratory tissue, teeth, and muscle. Even though the presence of dental tissue within dermoid cysts has been reported in the literature, the cysts containing jaw bone and teeth are extremely rare. We report a case of ruptured ovarian dermoid cyst containing jaw bones and eight well-formed teeth with a brief review of literature.
Subject(s)
Female , Humans , Cartilage , Cell Line , Dermoid Cyst , Hair , Jaw , Muscles , Ovarian Neoplasms , Ovary , Rupture , Skin , Suppuration , Teratoma , ToothABSTRACT
Isolated torsion of the fallopian tube is very uncommon during pregnancy. It usually confuses with acute appendicitis and torsion of the ovary. The diagnosis is usually established during operation, and a salpingectomy is almost always necessary. However, the early diagnosis and surgical treatment of the disease are mandatory to preserve oviduct. Because of safety and feasibility, laparoscopic surgery has recently become major treatment method.
Subject(s)
Animals , Female , Pregnancy , Appendicitis , Diagnosis , Early Diagnosis , Fallopian Tubes , Laparoscopy , Ovary , Oviducts , SalpingectomyABSTRACT
Malignant neoplasm of the fallopian tube is the rarest of the gynecologic cancers. Vaginal bleeding, vaginal discharge, and pelvic pain are the most common symptoms. Because of these non-specific symptoms, the diagnosis of this least common neoplasm is rarely made before laparotomy. The tumor is typically unilateral and has histologic subtypes, endometrioid and serous adenocarcinoma being the most common subtypes. Surgery, clearly the mainstay of treatment, is also the first approach to diagnosis. The procedure of choice is total abdominal hysterectomy with bilateral salpingo-oopho-rectomy. We had experienced one patient with primary tubal cancer, successfully evaluated with laparoscopy. And then we intend to report the case of the above patient and have a brief discussion about that.