ABSTRACT
Background: Thioacetamide is a liver toxin that causes centrilobular necrosis. In this study, the protective effect of fish oil omega3 supplements and aqueous extract of Glycyrrhiza glabra root against disorder in liver enzymes level induced by thioacetamide in male rats was investigated
Materials and methods: In this experimental study, 63 male rats were divided into 9 groups: The control group, the sham group, the thioacetamide group, the experimental groups 1-6. Experimental groups received a daily dose of 100, 200 and 300 mg/kg fish oil omega-3 supplements and the aqueous extract of Glycyrrhiza glabra root orally respectively for 3 month followed by an inter peritoneal dose of 150 mg/kg thioacetamide at the end of the experiment. The serum levels of SGOT, SGPT, ALP, GGT and LDH were measured
Results: The serum level of SGPT showed a significant decrease in the experimental groups 1, 5 and 6 compared to the group received thioacetamide. The serum level of GGT showed a significant decrease in the experimental groups 1, 2, 5 and 6 compared to the group received thioacetamide. The serum levels of SGOT, ALP and LDH in all experimental groups did not show significant changes compared to the group received thioacetamide [P<0.05]
Conclusion: Fish oil omega3 supplements and aqueous extract of Glycyrrhiza glabra root had protective effects against disorder in liver enzymes level induced by thioacetamide in male rats
ABSTRACT
Background: Components of olive oil include oleic acid, hydrocarbons [as squalene], sterols [as betasitosterol], polyphenols [tyrosol, hydroxyltyrosol, oleuropeinand, and others], tocopherols and terpenoids. Olive oil ingredients have anti-inflammatory, antioxidant, anti-arrhythmic, anti-inflammatory and vasodilatory effects. The present study was done to evaluate the effects of olive oil on kidney, lipid and liver function in male rat
Materials and methods: In this experimental study, 14 male rats were divided into 2 groups. In control group, each rat underwent no stress such as injection, oral gavage and etc. in experimental group, each rat received 0.4 mL olive oil orally per day for 3 months. All animals bled after 3 months. The blood samples were tested for creatinine, nitrogen urea blood [BUN], total cholesterol, LDL and HDL cholesterol, triglyceride, sodium, glucose, SGOT, SGPT, ALP, GGT, albumin and total protein serum levels
Results: No significant differences were noticed in sodium, BUN, total cholesterol, LDL cholesterol, HDL cholesterol and triglyceride serum levels in rats treated with olive oil compared to control group. There were no significant differences in SGOT, SGPT, ALP, GGT, albumin and total protein serum levels between rats treated with olive oil and control group
Conclusion: The results showed that olive oil had no effects on kidney, lipid and liver function