Evaluation and comparison of different brands of domperidone tablets available in Karachi, Pakistan

Domperidone is an anti-dopaminergic drug used for the treatment of nausea, vomiting and dyspepsia. It has also been used in Parkinson's disease. In this study, five different brands of Domeperidone tablets were selected from the local market for evaluation of their quality as the local market is occupied of many competitors for a single generic. The evaluation of Domperidone tablets was done using various pharmacopoeial and non-pharmacopoeial tests. All the test results fell within BP specified limits for all the selected brands i.e. the results for Brands A to E for weight variation, thickness and diameter were satisfactory and within limits. For Brands A to E, the results for hardness and friability were also satisfactory i.e. 4-10kg/cm2and 0.1-0.6% respectively. The results for Brands A to E for disintegration were 2-6 minutes; for dissolution and assay, the results were 89-92% and 95-99% respectively. The results of similarity factor [f[2]]also showed that all brands of Domperidone have comparative dissolution profiles

study of doppler waveform pattern of hepatic veins in patients of acute viral hepatitis in comparison with control population

The objective of this study was to evaluate hepatic vein flow patterns in adults with acute viral hepatitis and to compare the findings with a control group of healthy people using Doppler ultrasound. Cross-sectional comparative study Radiology Department Military Hospital and Combined Military Hospital Rawalpindi from 15 May 2007 to 15 November 2007. Eighty patients who underwent doppler ultrasound at Military Hospital and Combined Military Hospital Rawalpindi during the study period were divided into two groups of 40 each. Cases were selected from the Out Patient Departments of Military Hospital and Combined Military Hospital Rawalpindi. Group I comprised patients with diagnosis of acute viral hepatitis based on clinical and laboratory findings. Group II included the control group comprising 40 healthy volunteers. Doppler ultrasound of hepatic veins was carried out in both the groups of patients. Abnormal wave pattern of hepatic veins on Doppler ultrasound was noted in 35 [87.5%] in group I and in 1[0.25%] of group II. One patient having abnormal Doppler wave pattern in group II subsequently developed acute viral hepatitis. Doppler ultrasound assessment of wave pattern in hepatic veins is an accurate method to differentiate a diseased liver from a normal one. Doppler ultrasound of hepatic veins is a good technique to study disease status of liver