ABSTRACT
The aim of the study was to investigate the dissolution behavior of commercially available brands of metronidazole and to provide basic tool to evaluate the comparative effectiveness and interchangeability of generic brands under biowaiver conditions. The dissolution test for six brands of metronidazole 400mg tablets was performed and physical controls were analyzed. Basket Rack methods at 100rpm were used to estimate release pattern of drug. Pharmaceutical parameters of tablets were analyzed. In order to evaluate dissolution profiles, multiple point dissolution were performed and calculated 85.96 +/- 0.41 to 90.56 +/- 0.93 % within 15 minutes in pH 1.2,85.50 +/- 1.40 to 88.99 +/- 0.80% in pH 4.5 and 85.37 +/- 1.94 to 92.79 +/- 0.89% in pH 6.8 dissolution medium respectively. Five different kinetics have been studied to predict and evaluate the acceptability level of drug release. The results show that Hixson-Crowell, first-order and Weibull demonstrated the drug release with R2
ABSTRACT
To determine the seropositivity for viral hepatitis B, hepatitis C and HIV in healthy blood donor population of Northern areas of Pakistan. The blood donors attending the blood bank of Hayatabad Medical Complex, Peshawar were screened for seromarkers of viral hepatitis B, C and HIV by using enzyme linked immunoassay [ELISA] over a period of 05 years. The data of blood donor screening was obtained from Services Hospital, Peshawar for comparison. Blood donors screened at H.M.C. Hospital showed seropositivity of 1.40% and 1.34% for hepatitis B and hepatitis C respectively from 1999 - 2003. Screening of blood donors at Services Hospital, Peshawar during the same period, detected 1.75% HBsAg positive and 2.60% anti-HCV positive subjects. No HIV positive blood donor was detected in both the hospitals during this period. This study concluded a decreasing trend in the seroprevalence of viral hepatitis [B and C] in the blood donor population of Northern Pakistan