Effect of omega-3 supplementation on serum lipids in patients on chronic hemodialysis

Background: Considering the important of effects resulting from chronic hemodialysis in patients having renal insufficiency of which cardio-vascular effect is the most important, this study has been done to examine the complementary effects of omega lipid on lipid profile serum and systemic inflammation index in these patients.Methods: Patients in this study include two groups (intervention and control). They have been chosen from among the patient called on hemodialysis unit of Booali hospital. The interval group received one omega capsule daily and the control group received a placebo capsule one a day for three months. At the end, the results of lipid profile tests (including triglycerides (TG), low density lipoproteins (LDL) and high density lipoproteins (HDL)) and systemic inflammation index (C-reactive protein) compared before and after receiving the medicine.Results: In this study in interval group having omega3 despite decrease in TG and increase in HDL after three months there were no meaningful changes. In group receiving placebo only increase of HDL was meaningful and despite decrease in TG after receiving placebo these changes was meaningless.Conclusions: The results of this study showed that omega3 had no meaningful changes in lipidic profile of patients who were being hemodialysed.

relationship between COPD assessment test [CAT] scores and severity of airflow obstruction in stable

COPD is a major cause of morbidity in smokers. The COPD assessment test [CAT] is a validated test for evaluation of COPD impact on health status. CAT is not a diagnostic test and pulmonary function test [PFT] still remains the most important diagnostic test. However, its predictive value for evaluation of disease impact is weak. The purpose of this study was to determine the relationship between CAT score and PFT in COPD patients. We evaluated 105 patients with stable COPD. Demographic data were obtained at baseline. Severity of airflow obstruction was assessed by standard spirometry and classified by the Global initiative for Obstructive Lung Disease [GOLD] criteria. Then, the impact of COPD on health status was assessed using CAT. The CAT scores were categorized into four groups. We statistically compared the relationship between CAT score, COPD stages, CAT groups and PFT. The mean age of patients and mean period of smoking [p/y] were 59.60 +/- 11.93SD and 35.43 +/- 15.33 SD yrs, respectively. The mean FEV[1%predicted] was 71.01 +/- 26.70SD.The mean CAT score was 19.61 +/- 8.07 SD. The correlation between the severity of smoking and GOLD classification was significant [p=0.006].There was a significant association between the FEV[1%predicted] and total CAT score [r= -0.55, p< 0.001]. The correlation between mean FEV[1%predicted] and mean score of CAT groups 1, 2, 3, and 4 was statistically significant [p<0.001]. The relationship between CAT score and FEV[1%predicted] suggests that CAT is linked to severity of airflow limitation and GOLD classification in stable COPD patients. Health status as measured by CAT worsens with severity of airflow limitation