ABSTRACT
The methanol extracts of Mahonia leschenaultii Takeda [Berberidaceae] root and root bark were tested for antibacterial potential against Escherichia coli [NCIM 2068], Pseudomonas aeruginosa [NCIM 2053], Staphylococcus aureus [NCIM 2492] and Staphylococcus epidermidis [NCIM 2493], on nutrient agar medium and nutrient broth using ampicillin trihydrate as standard drug. For antifungal study strains used were Trichophyton lignorum [NCIM 1195] and Candida crusei [NCIM 3129], on Sabourauds dextrose agar [SDA] and Sabourauds dextrose broth [SDB] by cup plate method using amphotericin B as standard drug. The results showed that all extracts exhibited significant activity against all the selected strains of bacteria and relatively more against Staphylococcus epidermidis. The antifungal activity was less significant when compared with antibacterial activity