ABSTRACT
Introduction : Guillain-Barré syndrome (GBS) is a common cause of acute peripheral neuropathic disease. Electrodiagnostic studies (EDX) are important in diagnosis, classification, treatment and prognosis. Objective : To evaluate & define the early and common parameters of EDX for diagnosis of GBS. Methods : EDX of total 95 patients with clinical diagnosis of GBS were reviewed & analyzed. Results : Out of total 95 patients of GBS, 75 were demyelinating, 13 were axonal and 7 were of mixed type. In demyelinating group, there were 42 men and 33 women from ages 8 to 86; Hoffman reflex was absent in 100% patients; median sensory nerve action potential (SNAP) amplitude was abnormal in 66.6%patients compared to sural SNAP in 19.6%; F wave abnormalities, temporal dispersion and conduction block were found in 64%, 42.2% and 45% respectively. In axonal group, there were 7 men and 6 women from ages 11 to 83; compound motor nerve action potential (CMAP) amplitude was abnormal in (84%) studies & most commonly in tibial nerve. Conclusion : In demyelinating GBS, abnormal Hoffman reflex was found to be the most sensitive test and sural nerve sparing is frequently noticed. In axonal GBS, low CMAP in lower extremity was found the most sensitive test for diagnosis of GBS