ABSTRACT
Background: Pervious studies have suggested an association between adiposity, androgen and gonadotropin in late pubertal girls. Aim: Assessment the levels of gonadotropin and androgens among pubertal overweight and obese girls.subjects and Methods: it was a cross-sectional study, carried out in the obesity cilinic of diabetes, Endocrine and Metabolism Pediatric unit [DEMPU], pediatric Hospital, cairo University it included 40 overweight and obese girls and 40 age- matching normal weight [control] girls, aged [12-18] years. Anthropometric assessment; weight and height; was recorded, and BMI was calculated Laboratory investigations: serum luteinizing hormone [LH] and serum total testosterone were measured
Results: Hypogonadotrpins [LH] and hyperandrogenaemia [total testosterone] were significantly prominent among obese girls. gonadotropin had significant positive correlations with BMI
Conclusion: Obese girls had hypogonadotropins and hyperandrogeaemia. gonadotropin and androgen had significant opposing correlation with the anthropometric obesity markers defined as BMI
ABSTRACT
Background: Infectobesity' is a new term to describe obesity of infectious origin, such as infection by human adenovirus-36 [Adv36]. It appears to be a new concept, evolved over the past 20 years. Visceral obesity is associated with a higher risk of cardiovascular disease. Increased carotid intima-media thickness [CIMT], a marker of early-onset atherosclerosis, has been observed in obese children and adolescents. The present study aims to investigate the relationship between visceral obesity, CIMT, and Adv36 in female Egyptian adolescents
Patients and methods: The present study included 90 women aged 12-15 years. It was conducted at the Medical Excellence Research Center of the National Research Centre, Cairo, Egypt, during the period between September 2016 and November 2017. Anthropometric assessment was done. Fasting blood samples were withdrawn for the measurement of Qualitative Human Adv36 antibody using a sandwich enzyme-linked immunosorbent assay. Fasting plasma glucose was determined calorimetrically, by the glucose oxidase method and insulin level using the solid-phase enzyme-linked immunosorbent assay and lipid profile. Visceral obesity was measured by an abdominal ultrasound. CIMT for both carotid arteries were measured by high-resolution echo Doppler
Results: Girls with visceral obesity [n=26] had higher frequency of increased CIMT at left [96.2 vs. 75%], right carotid artery [84.6 vs. 73.4%] and Adv36 sero-positive antibody [69.2 vs. 56.2%] than among those without visceral obesity [n=64]. Among the total samples, visceral obesity had significant positive correlations with BMI, waist and hip circumference, while it had insignificant correlations with age, blood pressure [BP], CIMT at right and left carotid arteries, adenovirus and laboratory findings. CIMT had a significant positive correlation with each other, insulin resistance and total cholesterol, and significant negative correlations with high-density lipoprotein and waist circumference. Adv36 had significant negative correlations with BP [both systolic and diastolic] and significant positive correlation with insulin level. Adv36 and CIMT had insignificant correlations with each other and with the anthropometric measurements, BP, visceral obesity, triglycerides, and low density lipoprotein
Conclusion: The frequency of Adv36 and increased CIMT at left carotid artery were higher among girls with visceral obesity than among those without visceral obesity. However, visceral obesity, CIMT at both right and left carotid arteries, and Adv36 had insignificant correlations with each other
ABSTRACT
Background/Aim: measurement of carotid artery intima-media thickness [CIMT] is reliable for early detection of atherosclerosis, one of obesity's complications, which is a leading cause of mortality among patients with end-stage renal disease. The study aimed to evaluate CIMT in relation to obesity, chronic renal failure [CRF] and both, for the early prevention of cardiovascular problems
Patients and methods: this cross-sectional study included 118 adult individuals of both sexes, aged 30-60 years. Patients with CRF were gathered from the renal dialysis unit of King Fahd Hospital-Kasr El Einy Hospital, and the obese without CRF from the 'Management of Visceral obesity Unit', in' Medical Excellence Research Center [MERC]', National Research Centre, during the period spanning from June 2015 to April 2016.They were grouped into three groups: a case group, which included 45 obese individuals with CRF, and two control groups: one comprised 39 nonobese patients with CRF and the other group comprised 34 obese patients without CRF. Anthropometric assessment, lipid profile, and ultrasound measurement of CIMT were performed for each patient
Results: CIMT was greater in all groups than the normal range [0.06-0.08 cm], particularly in the obese group without renal failure. CIMT had a highly significant correlation with waist circumference and insignificant correlation with BMI and lipid profile in different groups
Conclusion: the increase in CIMT was related to obesity and renal failure, but it was more prominent with obesity. CIMT had highly significant correlation with central obesity in cases wherein obesity and renal failure were coexisting together and insignificant correlation with lipid profile