Study of coronary artery disease in patients of younger age group less than 40 years of age

Objective: To consider the aetiological factors for causing myocardial infarction in younger age group and to include these perspectives for the diagnosis of coronary artery disease. Study Design: A descriptive study. Place and Duration of Study: Study was carried out at CCU in the Department of Medicine, Avicenna Medical College and Hospital Lahore, from Jun 2012 to May 2013

Material and Methods: All patients within the age group of 26-35 years were admitted in CCU on the basis of multiple clinical symptoms by using approach of regular clinical investigations under the aspect of Ischemic heart disease. Clinical investigations were comprised upon cardiac monitoring, lipid profile, ECG and rate for cardiac enzyme included

Results: A total of 18 patients completed the study with age group of 26-35 years. MI was diagnosed in all patients and maximum number of patients with acute MI varied from age 28-33 years. All patients were heavy smokers with high rate of physical stress. On gross clinical examination it was revealed that majority of the patients included in age of 28-33 years was professionally van drivers

Conclusion: The essence of acute MI was observed and critically analyzed in younger age group of people with certain aetiological factors. This should be essentially important in redefining the criterion on clinical grounds for CAD and this should be recognized at International level. As the studies under clinical grounds with the aspect of CAD being reported at International level so, the amount of parameters in clinical diagnosis has to be considered in regular manners for the cure and prevention of CAD in patients especially of younger age groups less than 40

Ligand based pharmacophore development for colorectal cancer drugs

Focusing on the drugs used for chemotherapy and their associated side effects, there is a need to design and develop new anti-colon cancer drugs with lesser side effects and improved efficacy. Pharmacophore model proves to be a very helpful tool serving in the designing and development of new lead compounds. Place and Duration: Department of Bioinformatics, Mohammad Ali Jinnah University, Islamabad from January 2014 to May 2014. In this paper, pharmacophore of 4 novel anti-colon cancer compounds has been identified and validated for the first time. Using LigandScout the pharmacophore features were predicted and 3D pharmacophore have been extracted via VMD software. A training set data was collected from literature and the proposed model was applied to the training set whereby validating and verifying their similar activity as that of the most active compounds. The pharmacophore model is a very handy tool for new lead compounds discovery and development. In this study pharmacophore models were built for novel drugs of colorectal cancer and they could be recommended for further studies

Mody genes; linkage analysis and subgroup discovery from text documents

Genetic screening of Maturity Onset Diabetes of the Young [MODY] genes has not been performed in Pakistan so far; albeit MODY genes have been noticed in local population. A relevant research will help to establish a scheme for identification and treatment of MODY. The data source for the subgroup discovery was retrieved from PubMed. Family affected by MODY were contacted personaly for descriptive study. The family history was obtained from the representative members of the family and pedigree was drawn. The extensive clinical examination of both patients and their unaffected normal relatives was carried out by expert clinician. Specific primers for region of interest in genomic DNA were designed at the IBGE Islamabad using Primer 3 during last quarter of 2011. Mutation detection was performed followed by pattern discovery using subgroup discovery technique. Unidentified MODY genes facilitating the cause of a specific diabetes in European population may play a central role for diabetes characterized by autosomal dominant transmission in Pakistani population. Exclusion study indicates that there is no linkage to the known loci of MODY. Similarly genetic screening results suggest that no mutation is indicated in this examined family in MODY genes. There may be some environmental factors involved in causing this disease in this family; otherwise this disease is due to mutation in other reported MODY genes which are not screened in this study. Subgroup discovery results point out that all the reported MODY genes have association among themselves revealing 580 patterns