ABSTRACT
The aim of this study was to evaluate the effect of successful kidney transplantation [KT] on myocardial perfusion and left ventricular function by both qualitative [visual] interpretation and semiquantitative parameters, using myocardial perfusion scintigraphy with gated-single photon emission computed tomography [gated-SPECT] in patients suffering from end-stage renal disease. From a total of 38 patients who were candidates of KT, twenty-six patients [16 female, 10 male, mean age: 47.5 yr, range: 24-64 yr] who had successful KT were included. Myocardial perfusion scintigraphy was performed by Gated Single Photon Emission Computed Tomography [Gated-SPECT] method, before and after surgery [mean: 24 months]. Perfusion and function status was evaluated by qualitative and semiquantitative parameters. Our data showed qualitative evidence of perfusion and functional abnormality in pre-transplant scans as follows: Abnormal perfusion in left anterior descending [LAD], left circumflex [LCX] and right coronary artery [RCA] territories in 42.5%, 53.8% and 65.4% of cases, respectively; dilation in 57.7% and inhomogenity of uptake in 53.8% of cases. However no statistically significant change was noted after transplantation, i.e. p value for all semiquantitative values including summed stress score [SSS], summed rest score [SRS] and summed difference score [SDS], summed motion score [SMS], summed thickening score [STS], ejection fraction [EF], end diastolic volume [EDV], end systolic volume [ESV], and stroke volume [SV] was greater than 0.05. Renal transplantation may not have considerable long term effect on myocardial perfusion and function in patients with chronic renal failure. This could be due to either non-reversible myocardial changes or continuing effect of degrading factors on the myocardium
ABSTRACT
A 65year-old overweight man with a history of prostate cancer was referred to our nuclear medicine department for bone scanning. Anterior projection images showed two small foci of increased radiotracer uptake corresponding to the anterior arcs of the right and left sixth ribs, which were interpreted as suspicious for metastatic involvement. Eight months later the patient was referred for follow-up bone scan. In the follow-up scan, those two foci of abnormal radiotracer activity were outside the limits of the bony structures of the chest. In fact, those foci changed their position and were due to radiotracer uptake by the enlarged breasts of this gentleman [Gynecomastia]. Previously, it has been just one report concerning radiotracer uptake by the enlarged breasts of this gentleman [Gynecomastia]. Previously, it has been just one report concerning radiotracer uptake in the breasts of a man. Based on our case report, this abnormal finding is not exclusively observed in women and it can be also seen in men who suffer from gynecomastia. Physical examination in these settings can be extremely helpful. Oblique, lateral and SPECT [Single Photon Emission Tomography] views can also confirm the extraskeletal origin of radiotracer uptake
ABSTRACT
The field of stem cell biology and regenerative medicine is rapidly moving toward translation to clinical practice. Stem cell therapy seems to be a new treatment option for some diseases. So, tracking the distribution of stem cells is crucial to their therapeutic use. Based on this fact we labeled human mesenchymal stem cells [MSCs] with 111In-oxine for the first time in our country. The aim of this study was to investigate the possibility of stem cell labeling in Iran. In addition the researchers assessed the cell viability, specific activity and labeling efficiency after labeling. After culturing mesenchymal stem cells [MSCs], for radio-labeling, the sample [which contained 1x106MSCs] were mixed, and suspended with 50 micro Ci 111In-oxine, and then incubated for 20 min at the room temperature. The cells were then washed with normal saline twice to remove the free 111In. The labeling efficiency, specific activity and cell viability was 70.6%, 31.70 micro Ci/106 and 100%, respectively. It seems that, this method is practical and easily applicable with acceptable efficiency and specific activity in our laboratory settings using pharmaceutical produced in Iran