ABSTRACT
Cutaneous leishmaniasis [CL] is still a major health problem in many countries including Saudi Arabia. Patients with CL are seen, not only by dermatologists, but also by pediatricians and community physicians. Knowledge of available treatment options is essential. A literature review utilizing PubMed on Cochrane evidence-based library was undertaken in the last five years. Several medication and therapeutic modalities are currently in use, though the gold standard remains systemic antimonials. Drug resistance and serious side effects preclude the use of available medications. Newer therapies like liposomal amphotericin B, miltefosine and pentamidine are being used; while it is hoped that other drugs like imiquimod, tamoxifen, PDT and pentamidine structural analogs being tested would offer better efficacy, easier administration and lower toxicity. After decades of little advance in the treatment of leishmaniasis, there are now several options with newer compounds and combinations of these
Subject(s)
Leishmaniasis, Cutaneous/drug therapy , Amphotericin B , Pentamidine , Aminoquinolines , Tamoxifen , Phosphorylcholine/analogs & derivatives , Phosphorylcholine , Photochemotherapy , Evidence-Based Medicine , Drug Therapy, Combination , Combined Modality Therapy , Immunocompromised Host/drug effectsABSTRACT
Lipoid proteinosis is a rare autosomal recessive inherited metabolic disorder characterized by deposition of a hyaline-like material in the skin, oral laryngeal mucosa, and in other sites. In this report, the author describes 2 Saudi siblings who had characteristic skin findings, oral and mucosal lesions, histological findings along with few rarely encountered manifestations including pathognomonic calcifications in the hippocampus, electroencephalogram findings and briefly reviews the literature. These cases are presented to emphasize the occurrence of this condition in Saudi Arabia, and to update information on the latest developments of this disorder
Subject(s)
Humans , Male , Female , Lipoid Proteinosis of Urbach and Wiethe/pathology , Lipoid Proteinosis of Urbach and Wiethe/diagnosis , Tomography, X-Ray Computed , Review Literature as TopicABSTRACT
Even though laser and light-assisted hair removal have practically replaced electrolysis, there are situations when electrolysis is useful and advantageous. These situations include patients with dark skin, and those with vellous, accelerated vellous and white and red hairs. Furthermore, permanence of hair removal is achieved with electrolysis, though not certain with laser and light-assisted hair removal