Effect of immobilization on nerve conduction

Electrophysiological examination of the nerves in the immobilized [after linear, simple and closed fractures] disclosed an ample information regarding functional status of the nerves. Thirty nine patients [9 females and 30 males], having one upper limb immobilized by plaster of Paris were subjected in the study for measurement of motor and sensory conduction velocities of median and ulnar nerves. The conduction velocities were in both nerves. The distal motor latency of median and ulnar nerves was prolonged in immobilized limbs. These Findings showed clearly that immobilizatiaon produced neuropathic changes of variable degrees which need to be watched so that more serious disorders could be avoided

analysis of the response of the isolated rabbit jejunum to electrical stimulation and to drugs

The rabbit jejunum was investigated for tone and rhythmicity using an isometric isovolumic setup. Longitudinal and circular tension in addition to intraluminal pressure changes were recorded Periarterial and transmural electrical stimulations were applied and the responses were studied in the presence of hyoscine. neostigmine, hexamethonium, phentolamine and propranolol, guanethidine. And verapamil. Cholinergic block abolished the motor response to periarterial and transmural stimulations while physostigmine augmented it. Adrenergic block abolished the inhibitory response. When both cholinergic and adrenergic block was used the response to transmural stimulation was inhibitory followed by an after contraction. Verapamil abolished the rhythmicity and greatly reduced the motor response but did not affect the tone. Tone and rhythmicity in the rabbit jejunum are basically myogenic that are in fluenced by four types of innervation: excitatory cholinergic, non-adrenergic non-cholinergic, inhibitory adrenergic, and non-adrenergic non-cholinergic nerves

Electrophysiological investigation of tremor in thyrotoxic patients

Shaking of the hands is a well recognized sign of many diseases, among them thyrotoxicosis, which is called thyrotoxic tremor. The present study was carried out to understand the mechanism of tremor and to find whether there is a pattern of wave form specific to thyrotoxic tremor. The technique utilized the use of the accelerometric method of recording. The results obtained showed clearly that the amplitude [at three different positions] and the frequency of the tremor waves were significantly higher than that of normal physiological tremor. The tremor waves also showed a special pattern at the rest position of the hand. This was characterized by the presence of a burst of activities which was absent in normal subjects

Resting potential measurement of frog's muscle fibbers [Standardization of technique]

The microelectrode technique was described and used successfully. Measurement of the resting membrane potential of the sartorius muscle fibres in frog has been obtained and compared with previous findings reported by other workers. The technique is useful to carry further investigations on muscle, nerve and neuromuscular regions in normal and diseased conditions

electrophysiological attempt to identify the site of action of D-Tubocurarine

The sartorius muscle of the frog was used to investigate the neuromuscular region. Spontaneous subthreshold activity [mepp] was recorded by intracellular glass microelectrodes in normal and cutarized muscle. The amplitude of mepps in concentration of d-Tubocurarine [d-Tc] 5x10-13 to 5x10-11 g/1 showed a slight reduction in size; while a proflounced decrease in amplitude was noticed in concentration of 7.5x10-11 to 1 x10-6 g/1, indicating a stronger postjunctional effect in higher concentration. The effect of d Tc on the frequency of the mepps showed that the frequency was significantly increased in concentration of 5x10-13 to 5x10-11 g/1 of d-Tc. In concentration 1 x10-11 to 1 X10-10 g/1the frequency returned back to control level. Further increase in the drug concentration from 1 x 10-11 to 1 x 10-6 g/1 caused a steady reduction in the frequency of mepps indicating a pre-junctional effect of the drug. The conclusion obtained was that the present investigation has shown clearly both pre-and post-junctional effect of d-Tc and that the prejunctional effect should not to be under estimated

Experimental concussion in animals: a preliminary report

A technique has been designed to study the effect of experimental concussion on the intracranial pressure [extradural pressure], and some other auxiliary parameters. Our preliminary results are encouraging and ensuring that the technique applied is appropriate and could be used in the future for further investigation. Our future work aims to be correlated with the effect of head injury in the human