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2.
Article in English | IMSEAR | ID: sea-112935

ABSTRACT

The present paper describes the advantage/limitation of presently available 'in-vivo' methods to detect sensitivity status of Plasmodium falciparum to commonly used antimalarial drugs. The paper is based on a retrospective analysis of 890 P. falciparum cases and various parameters used to define the level of drug resistance. The presented quantification methodology with weightage system to different epidemiological variables of resistance may provide a guideline as to the level of parasite resistance, and a switch over to another antimalarial of firstline treatment which is of the considerable importance to provide early diagnosis and prompt treatment to avert the severe cases/deaths due to malaria.


Subject(s)
Animals , Antimalarials/therapeutic use , Drug Resistance , Health Planning , Humans , India/epidemiology , Malaria, Falciparum/drug therapy , Plasmodium falciparum/drug effects , Prevalence , Retrospective Studies
3.
Article in English | IMSEAR | ID: sea-112026

ABSTRACT

Plasmodium falciparum sensitivity test in "in-vivo" carried out in 450 patients revealed, parasite clearance in 66.45 percent cases with 25 mgm/kg body wt of chloroquine. Mean parasite clearance time (MPCT) of sensitive and R I, resistant cases reached near parallelism with an early recrudescence in RI cases indicating stabilisation of genetic change in the parasite strain. The analysis of data revealed that proportionately higher resistance was recorded in coastal area having deciduous (wet) forest ecotype followed by plains of deciduous dry forest and semi arid/arid ecotypes.


Subject(s)
Adolescent , Age Factors , Animals , Child , Child, Preschool , Chloroquine/pharmacology , Climate , Drug Resistance , Ecology , Humans , India , Infant , Malaria, Falciparum/drug therapy , Plasmodium falciparum/drug effects , Prevalence , Retrospective Studies
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