ABSTRACT
Aspirin [acetylsalicylic acid] is a widely used drug that possesses analgesic activity. It is effective in the treatment of pain, inflammation and fever. In addition to these ailments aspirin has been found to be useful in the treatment of other diseases including cell apoptosis and colorectal cancer, Kawasaki disease, migraine and cardiovascular diseases. The mechanism of action of aspirin is due to its ability to suppress the production of prostaglandin and thromboxanes as a result of its irreversible inactivation of cyclo-oxygenase [COX] enzyme
ABSTRACT
Cobalamins are complex organometallic compounds of biological interest present in animal food products including meat, eggs and milk. The clinically important cobalamins, i.e. cyanocobalamin [vitamin Bl2], hydroxocobalamin and methylcobalamin exist as coenzymes in biological system and are involved in several biochemical functions. The deficiency of vitamin B12 occurs mainly due to its malabsorption and results in pernicious anemia. This disease is age related and is associated with the destruction of parietal cells in the stomach. Clinical studies with high dose supplementation of cobalamins suggest a strong correlation between the duration of cognitive symptoms of the disease and the therapy. Neural tube defects and other birth defects have also been reported with cobalamin deficiency