ABSTRACT
Japanese encephalitis remains an important public health burden in Thailand despite japanese encephalitis vaccine has been employed in the Expanded Program of Immunization (EPI). Acute stroke or hemiparesis was an atypical feature in japanese encephalitis. We report a case of japanese encephalitis proven by demonstration of specific IgM antibody against JEV in serum with delayed presentation of left hemiparesis. No remarkably structural abnormality of brain parenchyma was detected by computer tomography (CT) and magnetic resonance imaging (MRI). With supportive treatment and physical rehabilitation, this patient has returned to fully normal neurological function.
ABSTRACT
The prevalence of TEL/AML1 fusion (translocation ets leukemia/ acute myeloid leukemia 1) in Thai children with B-cell precursor acute lymphoblastic leukemia (ALL), fluorescence in situ hybridization (FISH) was determined in 31 patients. TEL/AML1 translocation was detected in 10 patients (32.3 %). Other co-existing aberrations with TEL/AML1 were found including multiple copies of AML1 gene in 2 patients (6.4 %), TEL gene deletion in 5 patients (16.1 %). TEL gene deletion was observed in association with extra copies of AML1 in 1 case (3.2 %). DNA probe specific FISH revealed as a high-performance tool to exhibit TEL/ AML1 fusion in B-cell precursor childhood ALL patients. With high incidence of TEL/ AML1 fusion translocation detected by FISH in this study, further areas of chromosome alterations may be revealed using FISH technique. This should be beneficial in diagnostics and planning of treatment for the ALL patients.