ABSTRACT
Background and Objectives: Previous studies and biological mechanisms of carcinogenesis suggest that the steroid receptors content of breast epithelium may be related to breast cancer risk. The objective in this study was to determine the levels of estrogen receptor [ER] and progesterone receptor [PR] in neoplastic breast epithelium in breast cancer cases
Methods: Between May 2007 and May 2008 at private lab and hospitals [Zheen Hospital], [40] women and one man who were scheduled for diagnostic excisional biopsies of the breast to allow analysis of routinely resected tissue. Histological slides with neoplastic epithelium were available for the 41 cancer cases and neoplastic epithelium was examined with immunohistochemical assays to determine the status of epithelial cells staining for ER and PR
Results: The ER content of neoplastic tissue was higher in the left breast and within young age group cases. The PR content of neoplastic tissue was far lower in both side breast cancer cases but still left side breast cancer cases showing higher progesterone receptors. The relation between ER and PR contents of neoplastic tissue was observed
Conclusion: The results of this study are consistent with the indication of increased ER levels in neoplastic tissue in left breast cancer cases and progesterone receptor is also higher in left side breast cancers. This study contributes to the understanding of breast cancer by examining both ER and PR in neoplastic tissue