ABSTRACT
Introduction: Age-related macular degeneration (AMD) is a neurodegenerative disease which is one of the leading causes of vision loss affecting population above the age of 50 years. Of the two types wet and dry AMD, dry AMD constitute 90% of cases. Currently there is no effective treatment for AMD except for antioxidant supplementation which can delay the progression of AMD and its associated vision loss. In Ayurveda, it is a Vata Pitthadhika Drishtigata Roga compounded by Dhatukshaya in Vardhakya. The treatment should be Brimhana, Chakshushya and Rasayana to tackle the degenerative changes. Gandhaka Kalpa from Rasaratnasamucchaya and Ksheerabala 101 Avarti Taila has these properties to ameliorate the disease pathology. Hence a clinical study was planned with the objective to assess the effect of Gandhakakalpa internally and Ksheerabala 101 Avarti Taila Nasya in dry AMD. Methods: The study design was interventional, pre and post evaluation without control. After preparatory phase, patients were given Nasya with Ksheerabala 101 Avarti Taila followed by administration of Gandhaka Kalpa with concurrent administration of Ksheerabala 101 Avarti Taila as Pratimarsa Nasya. Study and follow up were done in 30 eyes. Results were documented and statistically analysed using Friedmains’s test, paired t test, Wilcoxon’s signed rank test and McNemar test according to type of variable. Result: The intervention is statistically significant while considering visual acuity (p < 0.001) and Daily Living Tasks Dependent on Vision questionnaire scores (p< 0.0001) and not significant for optical coherence tomography and Amsler grid findings. Conclusion: The intervention is an effective protocol to be followed in Ayurveda for dry AMD.
ABSTRACT
Background: Lateral condyle fractures of the distal humerus are the second most common fractures at the elbow in the paediatric population usually between the ages of 6-10 years old making up 5-20% of fractures in children. The aim of the present study was to assess the early results of patients with a displaced lateral humeral condyle fracture treated with open reduction and internal fixation. Methods: Our clinical trial was conducted involving 12 patients treated with open reduction and internal fixation (ORIF). Preoperative stage included clinical evaluation, routine investigations and radiological evaluation. Fractures were classified using the Milch. Patients were followed up weekly until radiological union of the fracture was evident. Results: 83.3% of our patients were males, while 16.7% were females. According to mechanism of injury, falling down continues to play a major role in causing disability. At (3-5) weeks all cases were with soft callus remove K wire; at 8 weeks, all cases were with union fracture; but at 12 weeks, one case (8.3%) was with mild stiffness and the rest was with full range of motion. As regards the carrying angle in our study, only 16.7% were with abnormal carrying angle. 33.3% were complicated; one case with mild limitation of motion and valgus; one case with varus and two cases with superficial infection. Conclusions: The open reduction and internal fixation of lateral humeral condyle fracture is the ideal treatment and it has a rate of complications