ABSTRACT
OBJECTIVE: this triple-masked controlled trial aimed to assess the effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in obese children and adolescents. METHODS: the study comprised 50 participants, aged 10 to16 years, who were randomly assigned into two groups of equal number. In this 12-week trial, one group received oral vitamin D (300,000 IU) and the other group received placebo. Cardiometabolic risk factors, insulin resistance, and a continuous value of metabolic syndrome (cMetS) were determined. Statistical analysis was conducted after adjustment for covariate interactions. RESULTS: overall, 21 patients in the vitamin D group and 22 in the placebo group completed the trial. No significant difference was observed in the baseline characteristics of the two groups. After the trial, in the vitamin D group, serum insulin and triglyceride concentrations, as well as HOM -IR and C-MetS decreased significantly, both when compared with the baseline and with the placebo group. No significant difference was observed when comparing total cholesterol, LDL-C, HDL-C, fasting blood glucose, and blood pressure. CONCLUSION: the present findings support the favorable effects of vitamin D supplementation on reducing insulin resistance and cardiometabolic risk factors in obese children. .
Este ensaio clínico triplo-cego controlado visa investigar os efeitos da suplementação de vitamina D sobre a resistência à insulina e os fatores de risco cardiometabólico em crianças e adolescentes obesos. O estudo contou com 50 participantes com idade entre 10 e 16 anos, aleatoriamente divididos em dois grupos de igual número de participantes. Neste ensaio clínico de 12 semanas, um grupo recebeu vitamina D via oral (300000 IU) e o outro grupo recebeu placebo. Foram determinados fatores de risco cardiometabólico, resistência à insulina e valor contínuo da síndrome metabólica (cMetS). A análise estatística foi conduzida após o ajuste das interações covariáveis. No todo, 21 pacientes no grupo vitamina D e 22 no grupo placebo concluíram o ensaio clínico. Nenhuma diferença significativa foi encontrada nas características de base dos dois grupos estudados. Após o ensaio clinico, no grupo vitamina D, as concentrações séricas de insulina e triglicerídeos, bem como HOMA-RI e cMetS caíram significativamente em comparação ao início do estudo; e também em comparação ao grupo placebo. Nenhuma diferença significativa foi vista ao comparar o colesterol total, LDL-C, HDL-C, glicemia de jejum e pressão sanguínea. Nossas conclusões indicam efeitos favoráveis da suplementação de vitamina D sobre a redução da resistência à insulina e de fatores de risco cardiometabólico em crianças obesas.
Subject(s)
Adolescent , Child , Female , Humans , Male , Dietary Supplements , Insulin Resistance/physiology , Metabolic Syndrome/blood , Obesity/blood , Vitamin D/administration & dosage , Vitamin D/blood , Vitamins/administration & dosage , Body Mass Index , Cholesterol/blood , Insulin/blood , Metabolic Syndrome/drug therapy , Risk Factors , Triglycerides/bloodABSTRACT
There are several evidences in favour of relationship of inguinal hernias and connective-tissue disorders. Soldiers are one susceptible group for inguinal hernia. The aim of this study is to evaluate the prevalence of Benign Joint Hypermobility Syndrome [BJHS] in soldiers and its relationship to inguinal hernias during training periods. This descriptive-analytic cohort study was done on soldiers of a military-base selected by easily-sampling method. Soldiers were divided into two groups of suffered from BJHS and healthy ones by using the beighton-scoring system for diagnosis of joint hypermobility. At the beginning, past history of inguinal hernia in two groups was assessed by history taking and physical examination. After 3months of training, two groups were reassessed and compared for new incidence of inguinal hernia. Collected data was statistically analyzed by SPSS version20 software using "Chi-Square" and "Mc-Nemar" tests. In this study 718 soldiers in two groups of suffered [211] and controls [507] were evaluated for presence of inguinal hernia. BJHS was detected in 29.4% of soldiers. At the beginning, a positive past history of inguinal hernia was significantly higher in case group [P-value=0.003]. After training period new occurrence of hernia was significantly higher in cases [1.4% against 0.2%, P-value=0.04] and this relationship was more clear in higher beighton scores [P-value=0.01]. Joint hyper-mobility and inguinal hernia have statistically significant relationship in soldiers and physical activities of training period cause higher incidence of hernia in suffered group than controls. Therefore in every case of BJHS, the presence of inguinal hernia should be noticed