Serum cholinesterase level as a biomarker in detecting liver injury in Patients with chronic hepatitis c

Background: hepatitis C virus can cause both acute and chronic hepatitis. The acute process is self-limited, rarely causes hepatic failure and usually leads to chronic infection. Chronic HCV infection often follows a progressive course over many years and can ultimately result in cirrhosis, HCC and the need for liver transplantation. Objective: the aim of this study is to evaluate serum cholinesterase (CHE) level as a biomarker for detecting liver damage in patients with chronic hepatitis C. Patients and Methods: the current study was carried out on 50 subjects selected from the outpatient's clinic of Internal Medicine Department of Sayed Galal Hospital, Al-Azhar University and admitted to the internal department. The study was performed in the period between July-2014 to July -2019. Results: Sensitivity of cholinesterase is 100%, its specificity is 100% and its accuracy is 100%, in predicting liver injury in patients with chronic hepatitis C. Cholinesterase is positively correlated with Hb, platelets and albumin. Cholinesterase is negatively correlated with ALT, AST and ALP, total & direct bilirubin, PT, INR, urea, creatinine and AFP. There is significant increase of cholinesterase among compensated compared with decompensated cirrhotic patients. There is significant decrease of cholinesterase among compensated cirrhotic patients compared with controls. There is significant decrease of cholinesterase among decompensated cirrhotic patients compared with controls. Conclusion: cholinesterase is an excellent biomarker of cirrhosis with good sensitivity and specificity. Cholinesterase shows good correlation with albumin, PT, INR and Child-Puch score. Cholinesterase distinguishes decompensated cirrhosis from compensated cirrhosis well

Complement and complement receptors in systemic lupus erythematosis and rheumatoid arthritis in children and adults

Complement 3, complement 4, properdin; and properdin C3b complex and Complement receptors [CR] [CR1 + CR11 and FC GAMA receptors] were studied in 61 patients. [8 - 20 yr.] 26 males, 35females, from AI-Azhar University Hospitals, 14 were SLE, 47 were RA. The results obtained were compared with 24 normal control. A significant decrease in C3, C4 in SLE and RA. A non significant difference in properdin in SLE and RA. A significant increase in P-C3b complex in SLE and RA. Asignificant decrease in CR1 receptor expression on neutrophils and lymphocytes of SLE, while no change with RA. Ahigh significant increase in CR11 expression on blood lymphocytes, in SLE but a non-significant difference with RA The results of FC GAMA receptor II expression on blood cells showed non significant difference in SLE and RA. Complement CR III expression on Blood cells showed a non significant diference in RA. The results of [FC- GAMA RIII] expression on monocytes showed significant increase and on neutrophils decreased and no difference on lymphocytes of SLE patients. From the study: C3, C4, and properdin-C3b complex can be used as an indicator of activity of the disease in SLE and RA inspit of no change of properdin Level. Also in cases in which C3 level is normal [30%] of SLE. Cases. C RI expression was found decrease on neutrophils of SLE while no change on expression in RA. It is possible to say that to diagnose SLE. C3, C4, P-C3b complex and CR1 expression should be measured to confirm the diagnosis of SLE

Role of CT scan in assessment of bronchiectasis

In recent years, CT which is clearly safer and easier to perform and causes no patient discomfort, has been used to establish the presence and extent of bronchiectasis. The aim of this work is to evaluate the role of CT scan in the diagnosis of bronchiectasis; 40 patients with a suspected clinical diagnosis of bronchiectasis were analyzed. The type, site and lobar distribution of bronchiectasis were scored. Although the pathologic types of bronchiectasis have a characteristic feature on CT, differentiation between the various forms is much less important than simple identification of the disease process itself. Spiral CT is a reliable method in assessment of bronchiectasis in patients enable to hold their breath but high resolution CT is a method of choice due to its greater sensitivity