Evaluation of redox profiles in exogenous subclinical hyperthyroidism at two different levels of TSH suppression

ABSTRACT Objective: Evaluate the relationship between exogenous subclinical hyperthyroidism and oxidative stress through the analysis of the redox profile of patients with subclinical hyperthyroidism exogenous (SCH) grade I (TSH = 0.1 to 0.4 IU/mL) and grade II (TSH < 0.1 IU/mL). Subjects and methods: We analyzed 46 patients with SCH due to the use of TSH suppressive therapy with LT4 after total thyroidectomy along with 6 control euthyroid individuals (3M and 3W). Patients were divided into two groups, G1 with TSH ≥ 0.1-0.4 IU/mL (n = 25; and 7M 14W) and G2 with TSH < 0.1 IU/mL (n = 25; and 4M 21W). Venous blood samples were collected to measure the levels of markers for oxidative damage (TBARS, FOX and protein carbonylation), muscle and liver damage (CK, AST, ALT, GGT) and antioxidants (GSH, GSSG and catalase). Results: Individuals in G2 showed a GSH/GSSG ratio ~ 30% greater than those in G1 (p = 0.004) and a catalase activity that was 4 times higher (p = 0.005). For lipid peroxidation, the levels measured in G2 were higher than both control and G1 (p = 0.05). No differences were observed for both protein carbonyl markers. G1 and G2 presented with greater indications of cell injury markers than the control group. Conclusion: TSH suppression therapy with LT4 that results in subclinical hyperthyroidism can cause a redox imbalance. The greater antioxidant capacity observed in the more suppressed group was not sufficient to avoid lipid peroxidation and cellular damage.

The influence of exercise order on strength performance in post menopause women / A influência da ordem dos exercícios sobre o desempenho da força muscular em mulheres na pós-menopausa

OBJECTIVE: Verify the influence of different exercise orders on the performance of the number of maximal repetitions in older women. METHODS: Twelve older women (65.7 ± 5.6 years, 66.9 ± 9.5 kg, 1.56 ± 0.67 m, 27.4 ± 3.6 kg/m2) underwent four nonconsecutive visits and two different orders of Resistance Training. At the first visit, the volunteers were submitted to anamnesis, anthropometric evaluation and a 10RM test. On the second visit, a re-test of 10RM was performed. On the third and fourth visits, the volunteers performed two exercise sequences: sequence A: bench press, latissimus pulldown close grip, biceps curl, triceps extension; for sequence B the order was inverted. Performance was measured by the number of repetitions in each exercise. To determine differences in performance for sequence A vs. sequence B, repeated measures were performed by two-way ANOVA followed by the Tuckey post-hoc test. RESULTS: The number of repetitions of each exercise varied significantly for the bench press, biceps curl and triceps extension between the exercise sequences. CONCLUSIONS: The order of the exercises performed in a resistance training session can affect the performance in the number of repetitions in older women.

OBJETIVO: Verificar a influência de diferentes sequências de exercícios no desempenho do número de repetições máximas em mulheres idosas. MÉTODOS: Doze mulheres idosas (65,7 ± 5,6 anos, 66,9 ± 9,5 kg, 1,56 ± 0,67 m; 27,4 ± 3,6 kg/m2) foram submetidas a diferentes sequências de exercícios no Treinamento Resistido. Na primeira visita, as voluntárias foram submetidas à anamnese, avaliação antropométrica e teste de 10 RM. Na segunda visita, foi feito um re-teste de 10RM. Na terceira e quarta visita, as voluntárias realizaram as duas sequências: SEQ A - supino horizontal, puxador alto fechado, rosca bíceps e rosca tríceps e, SEQ B - a ordem foi inversa. O desempenho foi medido pelo número de repetições em cada exercício. A fim de verificar as diferenças nos dados obtidos no desempenho em diferentes sequências e séries, foram realizadas medidas repetidas pela ANOVA two-way seguido do teste post-hoc de Tuckey. RESULTADOS: Os resultados demonstraram que o número de repetições de cada exercício variou significativamente entre as sequências nos exercícios de supino horizontal, rosca bíceps e rosca tríceps. CONCLUSÕES: A ordem dos exercícios realizada em uma sessão de treinamento resistido pode afetar o desempenho no número de repetições em mulheres idosas.

Efeito do treinamento de força na potência muscular de membros inferiores de idosos coronariopatas / Effect of resistance training on muscular power of lower limbs of elderly with coronary artery disease

Introdução: A força e a potência muscular têm relação direta com a capacidade funcional de idosos. Objetivo: Verificar o efeito absoluto e relativo da potência muscular de membros inferiores em idosos portadores de doença arterial coronariana. Métodos: Dez homens sedentários participaram de 24 sessões de treinamento de força compostas por 2 séries de 6 a 8 repetições máximas e 1 minuto de intervalo. No início, os exercícios foram: meio agachamento, step, flexão plantar. E após: extensão e flexão dos joelhos, adução e abdução do quadril sentado. A potência muscular foi mensurada nos momentos: pré, após 12 e 24 sessões. Resultados: Após 24 sessões de treinamento de força foram encontrados aumentos na potência muscular absoluta (p< 0.0001) e relativa (p<0.0001; p<0.0001) em relação à condição pré-treinamento, respectivamente. Conclusão: Vinte e quatro sessões de treinamento de força parecem ser suficientes para aumentar a PM absoluta e relativa de idosos coronariopatas. (AU)

Introduction: Strength and muscle power have a direct relationship with functional capacity in elderly people. Objective: Verify absolute and relative gains in muscle power of lower limbs in elderly people with coronary artery disease. Methods: Ten untrained men subjects participated of 24 sessions of resistance training composed by 2 sets of 6 to 8 maximum repetitions and 1 minute rest interval. Initially, the exercises were: half squat, step up and plantar flexion. And after: leg extension, leg curl, seated hip adduction and seated hip abduction. The muscle power was measured at times: pre, post 12 and 24 sessions. Results: After 24 sessions of resistance training were found increases in absolute muscle power (p< 0.0001) and relative (p< 0.0001) regarding the condition pre-training, respectively. Conclusion: Twenty four sessions of resistance training appear to be sufficient to increase absolute and relative muscle power in elderly people with coronary artery disease. (AU)