Markers of mitochondrial energy metabolism and their potential relationships with fatigue in human adults: a scoping review

This scoping review aimed to synthesize the best available evidence of the associations between molecular and genetic markers of mitochondrial metabolism and fatigue in human adults. The research question guiding this review was, "Are there potential relationships between mitochondrial metabolism markers and fatigue?" The literature search used three terms (mitochondria; fatigue; energy metabolism), which yielded 263 manuscripts and 22 theses/dissertations. The studies included in the review had to meet three criteria: (1) Include adult participants (≥18 years of age); (2) Show a relationship between mitochondrial energy metabolism and fatigue; (3) Be published in English, Spanish, or Portuguese. Of the 17 articles included for a full-text review, some had a cross-sectional design (6/17, 35%), and more than half (12/17, 70%) were published between 2015 and 2020. The predominant population studied were patients diagnosed with chronic fatigue syndrome (9/17, 53%). Most studies (15/17, 88%) assessed fatigue with validated instruments. Mitochondrial markers associated with fatigue are a) mitochondrial transport pathways and respiratory chain, b) mutations in mitochondrial DNA, and c) energy disorders in cells of the immune system, such as natural killer cells. Mitochondrial metabolic activities, such as the production and transport of ATP, are significant components that may help understand the etiology of fatigue. Future directions should include longitudinal study designs, characterization of fatigue phenotypes, and the identification of markers involved in production and transport pathways. The clinical relevance in this field can lead to interventions targeting mitochondrial markers to reduce or prevent fatigue.

Filipino-American nurses' knowledge, perceptions, beliefs and practice of genetics and genomics

@#<p style="text-align: justify;"><strong>INTRODUCTION:</strong> There is limited information on the   knowledge,   perceptions,   beliefs,   and practice, about genetics and genomics among Filipino-American   nurses.   The   National Coalition   of   Ethnic   Minority   Organizations (NCEMNA),  in  which  the  Philippine  Nurses Association  of  America  (PNAA)  is  a  member organization,  conducted  an  online  survey  to describe the genomic knowledge, perceptions, beliefs,  and  practice  of  minority  nurses.  This study   reports   on   responses   from   Filipino-American   survey   participants,   which   is   a subset analysis of the larger NCEMNA survey.<br /><strong>OBJECTIVE:</strong> The purpose of this study was to explore the knowledge, perceptions, beliefs, practice and genomic education of Filipino-American nurses.<br /><strong>METHOD:</strong>  An online survey of 112 Filipino-American nurses was conducted to describe the knowledge,  perceptions,  beliefs,  and  practice  of  genetics/genomics.  Survey  responses were analyzed using descriptive statistics.<br /><strong>RESULTS:</strong>  Most  (94%)  Filipino-American  nurses  wanted  to  learn  more  about  genetics. Although 41% of the respondents indicated good understanding of genetics of common diseases,  60%  had  not  attended  any  related  continuing  education  courses  since  RN licensure, and 73% reported unavailability of genetic courses to take. The majority (83%) of  PNAA  respondents  indicated  that  they  would  attend  genetics/genomics  awareness training if it was offered by their national organization during their annual conference, and 86%   reported   that   the   national   organization   should   have   a   visible   role   in genetics/genomics initiatives in their community.<br /><strong>CONCLUSION:</strong>  Filipino-American  nurses  wanted  to  learn  more  about  genetics  and  were willing to attend genetics/genomics trainings if offered by PNAA. The study findings can assist  PNAA  in  planning  future  educational  programs  that  incorporates  genetics  and genomics information. </p>