Adipokine Serum visfatin level in pregnancy induced hypertension and uncomplicated pregnancy

Background and Objectives: Hypertensive disorder in pregnancy is the significant disease that badly affects the maternal and fetal prognosis and lead to higher mortality and morbidity in the prenatal period. Visfatin, potentially a new adipokine has emerged having high contribution in pathogenesis of preeclampsia. The objective of the study was to find the level of Visfatin in pregnancy induced hypertension and normal pregnant women

Methods: This study was carried out in tertiary care hospitals, Peshawar from March-October 2014. A total of 234 pregnant women [gestational age >20 weeks] were included in the study with distribution as Preeclampsia [PE=86], Eclampsia [E=74] and control [N=74]. Blood was taken for measuring Visfatin level by Enzyme Linked Immunosorbent Assay [ELISA] technique. SPSS version 19 was used for statistical analysis. Student's t test was performed to evaluate the mean differences in patients and control

Results: Serum level of visfatin was significantly higher in pregnancy induced hypertension when compared with control [P value <0.001]. Comparisons of mean value of visfatin with age group of 21-40 years, body mass index [BMI], primary parous and parity 2-4, gestational age of >36 weeks and both systolic and diastolic blood pressure were highly significant in pregnancy induced hypertension when compared with control [p value <0.001]

Conclusion: Pregnancy induced hypertensive women showed increased level of serum Visfatin than normal pregnant women

Prevalence of asymptomatic bacteriuria in pregnant women

To study the prevalence of asymptomatic bacteriuria [ASB] in pregnant women of local population in Karachi. Prospective, hospital based conducted during September 2001-March 2002. Basic Medical Sciences Institute, Jinnah Postgraduate Medical Center Karachi. Group A [study group] consisted of 290 pregnant women attending the OPD of Gynaecology and Obstetrics units for antenatal check up and Group B [control] consisted of 70 nonpregnant women of fertile age. Midstream urine was collected and aerobically incubated at 37°C on CLED agar. Growth of >1x10[5] CFU/mL was taken as significant bacteriuria. Gram-negative bacteria were identified by API 20-E and gram-positive by standard routine methods. The two groups were age matched [P value>0.05]. Prevalence of asymptomatic bacteriuria was 6.2% [18/290] in the study group and 2.85%[2/70] in control group. E. coli was the common uropathogen in both groups and Staph. saprophyticus the second common only in-group A. Prevalence of ASB remained statistically the same in pregnant and nonpregnant women [P value >0.05] by X[2] application. Prevalence of ASB before pregnancy continues during pregnancy, if not treated. Uropathogens remain the same. All pregnant women should be screened for ASB by culture

Prostatic cancer - A retrospective study of 50 patients

This Objective of this study was to see histologic typing of prostate cancer and its relation to patient's age, as no curative therapy exists for the advanced stages. This is a retrospective study of 50 patients suffering from prostatic adenocarcinoma and admitted at Basic Medical Sciences Institute, Jinnah Postgraduate Medical Center Karachi. A total of fifty patients between ages of 50-80 years diagnosed during the period of 1990-2001 suffering from prostate cancer were included in this study. The result showed that maximum number of tumours were in age group ranging from 61-70 years, [58% of total cases]. Sixteen were [32%] well-differentiated tumours, twenty-eight [56%], moderately differentiated tumours and six [12%] were labelled as undifferentiated tumours. It was concluded that the majority of tumors were moderately differentiated tumours. Early diagnosis is useful for patients; because high grade tumours have bad prognostic markers

Surgical treatment of benign prostatic hyperplasia: outcome of transvesical prostatectomy

Benign Prostatic Hyperplasia [BPH] is a common disease in elderly people. Different treatment options i.e medical and surgical are available. Transvesical prostatectomy is commonly employed for BPH in our set up. The procedure is analysed and discussed in this prospective study. The objectives include the evaluation of the results of trans-vesical prostatectomy regarding short and long term complications, ways to bring down complications, manageability within the available resources and compare the out come with the reported literature about the treatment of BPH. The study was carried out at the District Head Quarter Teaching Hospital D. I. Khan from January 2000 to December 2002 i.e for a period of three years. A total of 209 cases of enlarged prostate were evaluated. Preoperative assessment of the patients for prostate size, status of urinary tract was done on admission, and bladder wash with normal saline carried out for 12-14 hours. Postoperative complications were recorded and compiled. Patients were discharged after removing catheter on 6th postoperative day and being able to pass urine. Patients were followed for 6 months to one year. Majority of patients presented between 50 and 90 years. Mean age was 63.43 years. Over all complications were 42%. Preoperative catheterization caused infection which played a major role in postoperative morbidity. Perioperative antibiotics and bladder instillation with povidone-iodine reduced infection. Transuretheral resection of prostate [TURP] is gold standard for BPH, however transvesical prostatectomy still has a place in modern urology and must be taught to trainees

Groin hernias: pattern of clinical presentation

To assess and analyze the presentation of disease, treatment options available in peripheral hospitals, postoperative complications, effects of delaying the surgery, evaluate the cost of treatment and choice of anesthesia. Material and A retrospective study of groin hernia was carried out in surgical ward of DHQ Teaching Hospital Dera Ismail Khan from Feb. 1999 to Dec. 2002. All the cases of groin hernia were admitted to surgical ward either as elective cases or through emergency. They were analyzed for age, sex, site and type of hernia, operative procedure under local or general anesthesia, post operative complications and duration of stay in the ward. Comparison of surgeon convenience and operative cost of cases under local or general anesthesia was made. A total 654 cases [0.9% of total admissions for the same period] were admitted out of which 585[89.5%] were elective and 69[10.5%] were through emergency. Distribution of cases was uniform along different decades of life with peak in the 1st decade. Male patients were 638[97.56%] and female patients were 16[2.44%]. Right side groin hernia were 423[64.8%], left side 211[32.1%] and bilateral hernia were 20[3.1%]. Over all complication rate was 11.02% and no mortality was reported in emergency or elective group of patients. Hospital stay was short [3.59 days], and operation under local anesthesia was convenient for patient and surgeon. Groin hernia is a common and relatively simple problem. It should be operated at the earliest and unnecessary delay can cause complications. Operation under local anesthesia is a viable alternative to general anesthesia

Minilaparotomy cholecystectomy - A review of 152 cases

This study was carried out in DHQ Teaching Hospital, DI Khan from January, 1999 to December, 2001. One hundred and fifty two patients with cholelithiasis were enrolled for the study. All the patients underwent minilap cholecystectomy and the results were analysed for mean operative time, hospital stay, post operative pain, complications and patient's acceptance on 1st and 2nd outdoors visits. Comparison was made with the reported results of laparoscopic cholecystectomy. The objective of this study was to analyse the results of cholecystectomy through a small muscle-splitting incision regarding complications rate, operative convenience and patient's acceptance of results. A reference has also been made to the literature about laparoscopic cholecystectomy to determine the place of minilap cholecystectomy in the present era. Mean operative time was 45 minutes [35 - 95 min], mean hospital stay was 4.5 days [2-11 days] with overall complication rate of 15%. Most of the patients were satisfied with the results of operation in terms of pain, participation in physical and social activities and postoperative scar. The procedure is affordable in our setup. As a conclusion mini lap cholecystectomy is the best alternate option to laparoscopic cholecystectomy in our set up because of technical and economic reasons. Compared to standard cholecystectomy it has great edge due to overall lower complications rate