ABSTRACT
Background: Type II Diabetes mellitus [DM] is a metabolic disorder that is characterized by high blood glucose because of the insulin resistance. Significant 1 more interest has been dedicated to the effect of type II diabetes on the brain. Along with cerebrovascular disease, type II diabetes is implicated in the development of other neurological co-morbidities
Aim of the work: To study cognitive functions in type II DM and the effect of insulin resistance on it
Subjects and methods: In the present study, cognitive function tests were done for 37 subjects; control [n= 17], type II DM [n= 20]. These tests include mini mental state examination [MMSE], Wechsler adult intelligence scale [WAIS], Wechsler memory scale [WMS] and Cognitive Event related potential [P300]. Circulating levels of glycosylated haemoglobin [HbA[1c]] and insulin were determined in venous blood samples of both groups
Results: MMSE was significantly lower in type II DM than control group [p-value = 0.034]. However no significant difference between type II DM and control group in WAIS and WMS except in visual reproduction [p-value = 0.048]. P300 latency was significantly longer in type II DM than controls [p- value 0.0001]. P300 amplitude was decreased significantly in type II DM than controls [p-value= 0.0001]. HbA[1c] and insulin was significantly higher in type II DM than controls [p-value= 0.0001]
Conclusion: type II DM is associated with cognitive impairment which may be due to insulin resistance