MRI features of posterior reversible encephalopathy syndrome

Background and Purpose: posterior Reversible Encephalopathy Syndrome [PRES] represents a clinico-radiological constellation of neurological symptoms and radiological features. The syndrome tends radiologically to be present with certain features and patterns. Our aim in this study is to investigate the PRES radiological features by which it does present in our community and to correlate the findings clinically

Methods: the MR images obtained for the 17 patients included in the study were analyzed for the PRES features and patterns. Fluid Attenuation Inversion Recovery [FLAIR] sequence was the mainly used sequence for assessment. Diffusion images with their apparent diffusion coefficient maps, T[2*] images, and Angiography were also utilized for further assessment and characterization

Results: most of the cases demonstrated a bilateral involvement [94%]. The regional distribution supra-tentorially included parietal and occipital affection in 94%, frontal lobe affection in 76%, and temporal lobe affection in 71%. Infra-tentorial involvement was noted in 41% of the cases. Pattern percentages were slightly different from those available in the literature with the Holo-hemispheric Watershed pattern being the most common [35%]

Conclusion: the originally described PRES features are present in the majority of the studied cases. The identified PRES patterns may reflect underlying clinical or pathological correlations, and hence can vary across communities

MR imaging features of chemotherapeutic neurotoxicity in cancer patient

Aim of the work: this study aimed to display the role of imaging by MRI in early detection and accurate diagnosis of chemotherapeutic neurotoxicity in neoplastic patients under chemotherapy

Patients and methods: this study included 50 cases of different cancers with CNS radiological manifestations. It included any cancer patient, regarding the age, sex and primary cancer and received any type of chemotherapy. The entire patients were evaluated by CEMRI technique, MR venography as well as diffusion weighted MRI

Results: our result showed different forms of neurotoxicity that occur in cancer patients due to the effect of chemotherapy such as posterior reversible encephalopathy syndrome and cerebral venous sinus thrombosis

Conclusion: all survivors of cancer patients should have lifelong follow-up, preferably with magnetic resonance imaging which provided greater anatomic detail and early detection of any abnormality