ABSTRACT
Non Alcoholic Fatty Liver Disease [NAFLD] is the most common cause of chronic liver injury, recently elevated uric acid [UA] level was found to be an important factor in the development of NAFLD so lowering the level of UA by allopurinol might play an important role in the improvement of NAFLD. The objective of the study is to evaluate the effect of treating hyperuricemia by allopurinol on NAFLD patients assessed by ultrasonography [U/S] and liver enzymes. 3l hyperuricemic patients suffering from NAFLD were enrolled in the study. These patients were randomly assigned into two groups; Group A [14 patients]: Placebo group who received starch based placebo for 2-3 months and Group B [17 patients]: Treatment group who received allopurinol for 2-3 months. Fatty liver [FL] grade and size were assessed by U/S before and after treatment; also liver enzymes [GPT , GOT] and UA were measured before and after treatment. The present study showed significant difference between GPT and GOT before and after lowering UA level [P<0.001 and P=0.013, respectively] in the treatment group while U/S parameters showed no significant difference in the FL size and grade before and after treatment [P:0.208 and 0.325 respectively]. We concluded that Allopurinol can be used to improve patients with NAFLD associated with hyperuricemia as assessed by improved liver enzymes
ABSTRACT
Lignin urethanes [carbamates] were prepared from dioxane lignin which was separated from saw dust of hard wood, supplied from a local workshop. Dioxane lignin is allowed to react with phenyl and ethyl isocyanate to form different lignin urethanes. The toxicological studies of the two derivatives were prepared to find out the interrelationship between the chemical structure and the toxicity induced by them. Determination of the LD30 showed that the phenyl lignin urethane is more toxic than the ethyl lignin urethane. The severity of toxic symptoms was found to be affected by the changes in the side chain. This has thrown some light on the way which we practically use for poisoning rats. The most active compound possesses higher molecular weight and a number of nitrogen atoms in the molecular formula. IR spectra revealed that the most active compound, phenyl lignin urethane has 1:2:4 aromatic beside 1:2: and 1:4 aromatic substitutions. Electronic spectra demonstrated that phenyl and ethyl lignin urethanes possess a shoulder peak at 280 mu than dioxane lignin [parent Cpd] due to more conjugated chromophores. Further studies are needed to support our conclusion