Mechanism of action of antihyperlipidemic drugs on fatty acide profile and lipid metabolism in rats

In this study, an induction of hyperlipidemia was performed by feeding male albino rats with 40% butter fat diet for a period of three months. Hyperlipidemic rats were subjected to two schedules of treatment [concurrent mid prophylactic] using daily oral doses of atorvastatin [Ator] in a dose of 0.9 mg kg-1 and etofibrate [Eto] in a dose of 45 mg kg-1 for a period of two weeks. Both concurrent and prophylactic treatments resulted in a progressive reduction in serum total cholesterol [TC] which reached its initial value when treated concurrently; while, serum low density lipoprotein- cholesterol [LDL- C] returned to its initial values with the two schedules of treatment with both drugs. These reductions were accompanied by hypotriacylglycerolemia in serum, liver, heart, kidney and depot fat. Both drugs elevated significantly the tissue contents of eicosapentenoic acid with the two schedules of treatment

Fatty acids profile of serum and tissues during therapeutic treatment with antihyperlipidemic drugs in female rats

In this study, induction of hyperlipidemia was performed in 60 female albino rats feeding a daily supplementation with 40% butter fat as fat diet content for a period of three months. Hyperlipidemia in rats resulted in a significant decrease in serum omega 6-polyunsaturated fatty acids [PUFAs], arachidonic acid [20.4] and in omega 3-PUFAs, docosapentaenoic acid [22.5]. Two schedules of treatment [concurrent and prophylactic] were applied in two groups of hyperlipidemic rats, each comprised 30 rats treated with antihyperlipidemic drugs [atorvastatin in a dose of 0.9 mg kg-1 and etofibrate in a dose of 45 mg kg-1]. In each mode of treatment, rats were subdivided into three groups, each comprised ten rats [one group subjected to atorvastatin treatment, the second group treated with etofibrate and the third group served as a control group for a period of two weeks]

Effect of curcumin on cadmium- induced hepatic toxicity in rats

The protective effect of spice principle, curcumin on cadmium [Cd] induced hepatotoxicity in rats were studied. Male albino rats injected i.v. with 4 mg CdCl[2]/Kg showed hepatic damage as measured by an increase in liver lipid peroxide product as malondialdehyde [MDA], glutathione peroxidase [GProx] and glutathione reductase [GRed]. On the other hand, hepatic superoxide dismutase [SOD] and reduced glutathione [GSH] content decreased significantly. The increase in liver MDA concomitant with elevated serum enzymes, alanine aminotransferase [ALAT], aspartate aminotransferase [ASAT] and lactate dehydrogenase [LDH]. Pre-administration of curcumin [30 mg/kg body wt.] for 7 days succeeded to ameliorate hepatic MDA. SOD and GSH in Cd-injected rats. The levels of GProx and GRed being normalized. Curcumin also lowered significantly serum ALAT, ASAT and LDH levels. These results elucidate the potent antioxidant protective action of curcumin against cadmium-induced hepatic damage as monitered by lipid peroxide and antioxidant enzymes