ABSTRACT
Burn injury is one of the most destructive events in the world. The Pergularia tomentosa L. is a medicinal plant that traditionally, applies for treatment of burning, in Bushehr province, Iran. Various bioactive compounds such as steroid glycosides, tannins, various vitamins, saponins, cardenolides and anthraquinones were identified into extract of the plant, which can be effective in burn wound healing. Twenty-one rats weighting every one 200+/-5 grams were divided equally into three groups. The second-degree burning induced on all groups. One of groups did not receive any treatment [The control group] and was treated locally with saline and eucerin. The Second group received the P. tomentosa L. as a topical ointment, and the third group received locally, a thin layer of silver sulfadiazine ointment 3% after washing the wound with saline. Afterward treatment period, the microscopic slides from histological sections were prepared. At that point, amounts of the fibroblast cells, blood vessels, wound area, necrotic tissues, and diameter of epidermis rate of wound healing were determined. Also the exterior status of wound in different days was considered. Results obtained from current study have revealed that the extract of P. tomentosa L. can significantly, cause qualitative and quantitative acceleration in healing of second degree burn wounds, due to their bioactive and vasoactive properties. In conclusion the P. tomentosa L. can is used as an overborne medicine with lower cost and side effect than the similar chemical medicines. Although, the further studies are needed on these plants, due to their some toxic effects
ABSTRACT
Background: Polycystic ovary syndrome [PCOS] is the most common endocrine disease and associated with insulin resistance. CXC Ligand 5 [CXCL5] is a new cytokine which is secreted from white adipose tissue during obesity and by blocking insulin signaling pathway inhibits the activity of insulin and promotes insulin resistance
Objective: The aim of this study was to assess serum level of CXCL5 in PCOS women with normal body mass index
Materials and Methods: In this case-control study, 30 PCOS women with normal body mass index as the case group and 30 non-PCOS women as the controls were enrolled. Serum levels of CXCL5, insulin and other hormones factors related with PCOS were measured by ELISA method, also the biochemical parameters were measured by auto analyzer
Results: Significant increases in serum insulin concentration, homeostasis model assessments of insulin resistance, luteinizing hormone, luteinizing hormone/follicle-stimulating hormone, fasting blood sugar, testosterone, and prolactin were observed in the case group compared to the controls. were in the serum level of CXCL5, cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, dehydroepi and roster one-sulfate, creatinine, and homeostasis model assessment of beta cell function between these two groups
Conclusion: In this study, no significant change was observed in serum concentrations of CXCL5 in PCOS women with normal BMI
ABSTRACT
Background: Anabolic-Androgenic Steroids [AAS] are mainly abused by athletes for improvement of muscle performance. Data suggest that the effect of AAS on neurobio-chemicals related to behavioral response, may be underlies psychological adverse effects
Physical activity has beneficial psychophysiological effects, which may be related to increased serum levels of endogenous opioid peptides during exercise. In the present study we aimed to study the effect of chronic administration of nandrolone decanoate on beta-endorphin and met-enkephalin level in exercising rats
Methods: In this experimental study, forty male Wistar rats were randomly assigned in two main groups of sedentary and trained [2 weeks swimming exercise]
Animals in each group were divided in two subgroups of control [received nandrolone solvent] and drug treatment [received nandrolone 15 mg/kg, 5 times/week]. After two weeks of swimming exercise and drug treatment, serum levels of beta-endorphin and met-enkephalin were measured using ELIZA
Results: Our data showed that two weeks of swimming exercise training significantly increased serum beta-endorphin [114+/-5 vs. 98+/-5 ng/1 in control group, P= 0.038] and met-enkephalin levels [1556+/-42 vs. 1475+/-27 ng/1 in control group, P= 0.25]
However, chronic administration of nandrolone decanoate in trained group considerably decreased beta-endorphin [84+/-4 vs. 114+/-5 ng/1 in control group, P= 0.002] and met-enkephalin levels [1378+/-36 vs. 1556+/-42 ng/1 in control group, P= 0.011]
The effect of supraphysiologic doses of nandrolone decanoate in control sedentary group was not statistically significant
Conclusion: In the present study we show that chronic nandrolone decanoate administration attenuates effects of two weeks swimming exercise on serum opioid peptide and reduces the level of beta-endorphin and met-enkephalin. Keeping in mind that opioidergic system play an important role in behavior, athletes abusing anabolic steroid drugs may potentially experience changes in mood and behavior
ABSTRACT
Lithium is widely used in medicine as an anti-depressive drug. In spite of abundant literature, questions on the side effects of lithium ions are far from being answered. In this study, the effects of lithium on biochemical parameters related to lipid metabolism were investigated. Male Wistar rats were treated with different doses of lithium for a period of up to 60 days. Blood samples were collected and livers were removed for analysis. Lipid related parameters in plasma and livers were measured by st and ard methods. Epididymal fat pads were used to investigate the mechanism of lithium action on lipolysis. It is shown that the major effect of lithium is reduction of HDL-C concentration and the increase of LDL-C only in high doses. Lithium treatment led to a decrease in liver content of triglycerides but phosphohpids increased significantly. Lithium also showed to inhibit lipoprotein lipase activity. This inhibitory effect is potentiated in the presence of citrate. Fat cell lipolysis is also inhibited by lithium, which is not reversed by alpha, and beta-receptor blockers indicating that lithium may exert its effect beyond these receptors. Lithium changes the metabolism of lipoproteins. The finding that lithium decreases HDL and increases LDL concentrations should be considered seriously, especially in patients using this drug for a long period