ABSTRACT
This study aimed to determine the significant prognostic factors in patients with advanced Hodgkin's disease [stage III B and IV] treated by chemotherapy alone or chemoradiotherapy and the evaluation of the results regarding the response to treatment and four years survival. Analysis of the results showed that there were five prognostic factors adversely affect the response to treatment and over all survival; age, anemia, number of extra nodal sites, LDH and lymphocytic count. 96.6% of cases of stage III B were in complete remission [CR] versus 53.6% only of stage IV cases. Patients at high risk whom had three or more adverse variables their response to the treatment was 57.6%, while patients with less than three adverse variables was 79%. The four years survival was 91.1% for patients with less than three adverse variables and was 78% for patients with more than three adverse variables