ABSTRACT
We described the clinical picture of the eyes together with the laboratory findings of an African adolescent during the sero-negative stage of HIV infection who presented clinically with bilateral panuveitis with mild reaction in both the anterior chamber and vitreous. The fundus showed plaques that could be cotton-wool spots and pigmentary changes. Based on the presence of eosinophilia, a drop T-helper / T-suppressor together with a drop of B-cell total number, absent delayed hypersensitivity together with multiple opportunistic infections in the form of toxoplasmosis, the case was diagnosed as acquired immune deficiency [AIDS]. The patient was sero - negative at presentation, but sero-conversion occurred five months later. The importance of antigen detection in cases of suspected immunodeficiency is emphasized