ABSTRACT
to evaluate the role of metformin during pregnancy in women with polycystic ovaray synderome [PCOS] about safety,early pregnancy loss and developmental gestational diabetes. sixty six women with PCOS conceived spontaneously on metformin only or with induction of ovulation by clomiphene citrate, hCG, HMG.in outpatient clinic in El-Hussein hospital and my private clinic, outcomes including numbers of early pregnancy loss, number of live births, gestational diabetes [G.D] and congenetal defects [CD] intrauterine or in neo-nates. Results.of the 66 pregnant women with PCOS, early pregnancy loss in metformin group 4/42 [9.5%], and in control group 10/24 [41.7%] P=<0.001. number of live births in metformin group and in control group 38/42 [90.5%],14/24 [58.3%], respectively [p= <0.001]. development of Gestational diabetes in metformin group and in control group 2/42 [4.8%],5/24 [20.8%] respectively,[p= <0.001].no advesre fetal outcome in both groups. serum testosterone in both groups not differ at base line but at 6-12 wks of gestation significantly lower in metformin than control group 1.42 +/- 0.12 vs 3.32 +/- 0.24 ng/dl respectively [p=<0.001].metformin therapy during pregnancy in women with PCOS was safely associated with reduction in spontaneous early pregnancy loss,gestational diabetes with no teratogenic effects