Synthesis, spectral analysis and antibacterial activity of some novel 5- substituted-2-[[6-bromo-3,4-methylenedioxybenzyl]thio]-1,3,4- oxadiazole derivatives

A number of novel 5-substituted-2-[[6-bromo-3,4-methylenedioxybenzyl]thio]-1,3,4-Oxadiazole derivatives [6a-l] have been synthesized to evaluate their antibacterial activity. Using aryl/aralkyl carboxylic acids [1a-l] as precursors, 5-substituted-1,3,4-Oxadiazol-2-thiols [4a-l] were yielded in good amounts.The derivatives, 4a-l, were subjected to electrophilic substitution reaction on stirring with 6-bromo-3,4-methylenedioxybenzyl chloride [5] in DMFto synthesize the required compounds. All the synthesized molecules were well characterized by IR, [1]H-NMR, [13]C-NMR and EIMS spectral data and evaluated for antibacterial activity against some bacterial strains of Gram-bacteria. The molecule, 6d, demonstrated the best activity among all the synthesized molecules exhibiting weak to moderate inhibition potential

Pain management: an overview

Pain is an unpleasant sensory and emotional experience caused by actual or potential tissue damage. This damage is nature's warning that something is not well within the body. This condition causes loss of workforce and also affects the patients family members in socio-economical and psychological terms. There is an increase in knowledge regarding pain management in recent years. These developments in pain management may provide different opportunities to the patient and their families to lead a more comfortable and productive life. Managing pain is not about making it disappear rather it is about keeping it under control. The aim is not to stop pain in its stride, but to avert the damage caused by it. Prolonged pain is demoralising and debilitating and should be controlled as fast as possible and with all possible means. For this reason in addition to pharmacological treatment now a days non pharmacological treatment options are on rise

Tuberculosis control: current status, challenges and barriers ahead in 22 high endemic countries

Despite the fact that Directly Observed Treatment Strategy [DOTS] short course is cost effective and universally recommended by WHO for effective TB control, it is beyond the financial reach of several highly endemic countries. This article aims at identifying barriers in DOTS's implementation and progress in 22 high burden countries [HBCs] from TB. Medline abstracts, published papers and WHO reports were retrieved, critically examined and compared keeping standard parameters of TB control in view. Results and The increasing caseload, morbidity and mortality due to TB in high burden countries have become a major health challenge and threat to the health systems. The escalated burden of disease and deaths due to TB has posed a great threat to the international security. In the last decade little progress has been witnessed in the implementation of WHO's recommended strategy called DOTS in the 22 high burden countries. Afghanistan, Pakistan, India, Brazil, Zimbabwe, S. Africa and Uganda are some of the countries still facing challenges in the effective introduction, implementation and expansion of DOTS. Financial inabilities contribute greatly to the failure of respective national TB control programs. High burden countries are usually in the economic recession or passing through severe socio-political turmoil that has further reduced spending on TB control. Majority depends on the international assistance and put little domestic efforts. Coupled with the lack of political commitment to the issue of TB control, authors urge high TB control Program managers in HBCs to increase spending and pay a great deal of commitment to the universal implementation of DOTS, increase case detection and case management to attain their global targets