Protective role of ascorbic acid on population of -T- lymphocyte in major salivary glands of rat exposed to cadmium [immuno-histochemical study]

The study was carried out to evaluate the immunohistochemical investigation of the protective role of ascorbic acid on population of T-lymphocyte in major salivary glands of rat exposed to cadmium. Fifteen male rats weighting about 250g, were divided into three groups, 5 animals for each. In group I, the rats were injected with 0.5 ml of physiological saline and used as control. In group II, the animals were injected with cadmium chloride [15mg/kg body weight] for 1.4 and 8 weeks. In group III, the rats were injected with cadmium chloride simultaneously with ascorbic acid for different periods equal to the periods cadmium chloride injection. The results demonstrated that, by using of the anti-CD3 monoclonal antibody, the immunohistochemical finding of group II demonstrated weak positive staining with anti-CD3 antibody and a few number of positive T lymphocyte was situated in the connective tissue storma, as well as, parenchymal tissue of salivary glands. In group III, strong positive reactivity with anti-CD3 antibody in all examined tissue. There was great number of anti-CD3 positive T-lymphocyte scattered in the glandular tissue than that seen in group II. The ascorbic acid demonstrated beneficial effect on the cadmium toxicity exposed salivary gland when both drugs were simultaneously administrated and toxic effect of cadmium on the immune system can be obliterated by a sufficient intake of ascorbic acid. We conclude that immune functional abnormalities can be restored after toxic chemicals exposure by oral usage of ascorbic acid

Tooth lead concentration as an indicator for environmental lead pollution in Cairo

A comparison of lead burden of children deciduous teeth collected in suburban and urban areas of Cairo was undertaken. This comparison was determined by calculating the concentrations of lead levels in teeth shedded from children living in both regions. A significant correlation was established and the results proved that children who live in Cairo City have a relatively high degree of tooth lead contamination, especially in the urban area. These data should encourage the Egyptian authorities to increase the control of lead emission sources