ABSTRACT
PURPOSE: The purpose of this study was to compare the effects of resiniferatoxin (RTX) and botulinum toxin (BTX) on the bladder detrusor function in a cyclophosphamide (CYP)-induced cystitis rat model. MATERIALS AND METHODS: Sprague-Dawley rats were divided into 5 groups (1: saline treated, 2: CYP and BTX treated, 3: CYP and RTX treated, 4 and 5: CYP treated and sham operated as the counterpart of groups 2 and 3, respectively, with normal saline). 100mg/kg CYP was injected every third day for five weeks. Cystometrograms were performed after the BTX and RTX treatments. RESULTS: 1. The normal control group and the CYP-treated only group. In the CYP-treated group, the time of micturition frequency, the maximal detrusor pressure on the cystometergram (Pvesmax at CMG), the maximal detrusor pressure on the pressure-flow study (Pvesmax at pr/flow) and the episodes of irregular contractions were increased. 2. The CYP-only group and the CYP/BTX or CYP/RTXtreated groups. In the CYP/BTX or CYP/RTX treated groups, the time of micturition frequency, the Pvesmax at CMG, the Pvesmax at pr/flow and the episode of irregular contractions were decreased. 3. The CYP/BTXtreated group and the CYP/ RTXtreated group. There was no statistically significant difference between the two groups regarding micturition frequency, the PvesMax at CMG and the PvesMax at pr/flow, the Dhfo and the episodes of involuntary contractions (p>0.05). CONCLUSIONS: Intravesical administration of BTX or RTX blocked the CYP-induced detrusor overactivity as was shown by the restoration of the micturition frequency, the intravesical pressure and the involuntary contraction episodes to a control level. There was no statistically significant difference between the two groups regarding the urodynamic parameters.
Subject(s)
Animals , Rats , Administration, Intravesical , Botulinum Toxins , Cyclophosphamide , Cystitis , Models, Animal , Rats, Sprague-Dawley , Urinary Bladder , Urination , UrodynamicsABSTRACT
Enterovesical fistula is a relatively uncommon complication involving colorectal and pelvic malignancies, intestinal diverticulitis, inflammatory bowel disease, radiotherapy and trauma in Asian countries. A 77-year-old male was referred with complaints of difficult urination, frequency, nocturia and abdominal discomfort. On admission, fever and fecaluria were present. Various diagnostic procedures such as excretory urography, cystography, cystoscopy, rectoscopy and pelvic computed tomography (CT) scan were performed. Under the impression of vesicosigmoidal fistula, segmental resection of the sigmoid colon with partial cystectomy was performed. The histopathology revealed diverticulosis of the sigmoid colon with diverticulitis and development of a vesicosigmoidal fistula.
Subject(s)
Aged , Humans , Male , Asian People , Colon, Sigmoid , Cystectomy , Cystoscopy , Diverticulitis , Diverticulum , Fever , Fistula , Inflammatory Bowel Diseases , Nocturia , Radiotherapy , Urination , UrographyABSTRACT
A malignant fibrous histiocytoma is a rare pleomorphic tumor of the soft tissues. Primary retroperitoneal involvement of a malignant fibrous histiocytoma is very rare and often diagnosed in an advanced stage as it has no specific symptoms. Herein, a case of a malignant fibrous histiocytoma involving the retroperitoneum is reported, which was incidentally found in a 74-year-old male, who complained of pain in the right abdomen and thigh.