HLA Profile in Iraqi rheumatic valvulitis patients

Human leukocyte antigen [LILA] is the most polymorphic genetic system in man. The genes of this region influence susceptibility to certain disease. This study was established to shed light on the possible association of HLA class I and II antigens with RV patients. Lymphocvtotoxicity assay for HLA for class I and II typing had been done for [100] iraqi patients suffering from rheumatic valvulitis [RV] the control groups consisting of [75 healthy individuals and 35 non rheumatic heart disease [NRHD] patients]. The results showed a significant association of A33-Ag with these patients as compared with healthy and cardiac controls [P=0.005][P=0.033] respectively. Another interesting finding was the low frequency of AI in RI patients when compared with heal/he control [p=0.002], suggesting that Al allele may confer protective effect against this disease. In addition significant association between blood group B and RV was evident [p=0.04] An interesting observation was a strong association of blood group B and A33 among those patients [P < 0.001]. The present results are consistent with hypothesis that susceptibility to RV is genetically linked and in turn may be associated mainly with A33 in Iraqi patients

Preoperative and Postoperative Serum Immunoglobulins Levels in Colorectal Cancer of Iraqi Patients

Quantitation of serum immunoglobulins [IgG, IgA and IgM] provides useful information for the evaluation of certain cancers. to estimate serum immunoglobulins level before and after surgery, and to shed light on the correlation of immunoglobulins with progression of CRC. By single radial immune diffusion method IgG, IgA, IgM were estimated in 100 CRC patients preoperatively, and in 20 patients postoperatively compared with 35 patients control with ulcerative colitis [UC] and 50 healthy control. The study showed significantly increased the serum IgM level in patients group preoperatively [p < 0.001] compared with control group. On the other hand, no significant differences were observed in respect to the mean of IgG, IgA, and IgM after surgical excision of the tumor in 20 patients. These finding suggests that high level of IgM might be considered as prognostic indicator

Possible association of HLA-DR and DQ molecules with colorectal cancer in Iraqi patients

Human leukocyte antigen [HLA] is the most polymorphic genetic system in man. The genes of this region influnence susceptibility to certain diseases. This study was established to shed light on the possible association of HLA class-II antigens and CRC patients, and to correlate the findings with both family history and tumor location. Microlymphocytotxicity assay has been used to assess HLA-typing of 150 blood samples of 100 CRC patients and 50 healthy normal control. An increased frequency of HLA-DR7 was observed for patients' group versus control group with P-value [<0.005], moreover, statistical analysis showed non significant correlation of HLA-DR7 with both family history of CRC and tumor location. This finding demonstrate that HLA-DR7 might play a role in CRC susceptibility